The impact of dark chocolate intake on arterial elasticity in individuals with HIV/AIDS undergoing ART: a randomized, double-blind, crossover trial

Food & Function
Andrea Mariana Nunes da Costa TeixeiraPatrícia Helen de Carvalho Rondo

Abstract

An increase in the frequency of cardiovascular diseases has been observed in the HIV/AIDS population. Studies involving healthy subjects or subjects with other diseases have shown benefits of chocolate supplementation on endothelial function and vasodilation. We evaluate the impact of chocolate consumption on arterial elasticity in people living with human immunodeficiency virus - PLHIV. A double-blind, crossover trial including 110 PLHIV (19 to 59 years) on antiretroviral therapy - ART for at least 6 months and with a viral load of <500 copies per mL was conducted. All subjects were randomly assigned to 15-d dietary supplements containing dark chocolate or placebo with a 15-d washout period. Each participant received one of the two sequences: A (dark chocolate, placebo chocolate); B (placebo chocolate, dark chocolate). Arterial elasticity was measured using the HDI/PulseWave™ CR-2000 CardioVascular Profiling System®. Body composition, lipid profile, C-reactive protein, and thiobarbituric acid reactive substances were also assessed. Analysis of variance (ANOVA) for repeated measures using the Stata 11.0® program was used for cross-over analysis. Most subjects were men (59.0%) and Caucasian (46.1%) and the mean age was 44.6 ± 7....Continue Reading

References

Jun 11, 2002·Blood Pressure Monitoring·L M PrisantS M Hollenberg
Aug 29, 2003·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Neera Singhal, James Austin
Feb 17, 2005·Clinical & Developmental Immunology·Cesar G FragaCarl L Keen
Jun 1, 2005·American Journal of Hypertension·Charalambos VlachopoulosChristodoulos Stefanadis
Jul 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirofumi TomiyamaAkira Yamashina
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hagen SchroeterMalte Kelm
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Christian HeissMalte Kelm
May 12, 2007·The American Journal of Cardiology·Charalambos V VlachopoulosChristodoulos I Stefanadis
Apr 9, 2008·Clinical Science·Patricia H C RondóLuiz Roberto Innocente
Jun 19, 2008·Hypertension·Giuseppe SchillaciElmo Mannarino
Jul 11, 2008·The American Journal of Clinical Nutrition·Zubaida FaridiDavid L Katz
Jan 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marit G A van VonderenMichiel A van Agtmael
Feb 24, 2009·Critical Reviews in Food Science and Nutrition·Francesco VisioliRodolfo Paoletti
Mar 18, 2009·Circulation·Roberto CortiThomas F Lüscher
Sep 5, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jason V BakerKeith Henry
Feb 14, 2012·Nutrition Journal·José Ignacio Recio-RodríguezUNKNOWN Vaso-Risk group
Jul 25, 2012·The Clinical Respiratory Journal·Thomas BlankenburgWolfgang Schuette
Mar 6, 2013·JAMA Internal Medicine·Matthew S FreibergAmy C Justice
Mar 28, 2013·International Journal of Hypertension·Jenifer d'El-ReiFernanda Medeiros
Apr 16, 2013·Revista da Associação Médica Brasileira·Suelen Jorge SouzaPatrícia Helen Carvalho Rondó
May 8, 2013·Molecular Nutrition & Food Research·Sara ArranzRamon Estruch
May 25, 2013·Journal of Clinical Biochemistry and Nutrition·Naomi Osakabe
Apr 1, 2014·Heart & Lung : the Journal of Critical Care·Santo DellegrottaglieJavier Sanz
Apr 2, 2014·Annals of Internal Medicine·Wendy S PostLisa P Jacobson
Nov 6, 2015·The American Journal of Clinical Nutrition·Javier I OttavianiCarl L Keen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.