The Impact of Delays to Definitive Surgical Care on Survival in Colorectal Cancer Patients

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Maude TrépanierLawrence Lee

Abstract

Treatment delay may have detrimental effects on cancer outcomes. The impact of longer delays on colorectal cancer outcomes remains poorly described. The objective of this study was to determine the effect of delays to curative-intent surgical resection on survival in colorectal cancer patients. All adult patients undergoing elective resection of primary non-metastatic colorectal adenocarcinoma from January 2009 to December 2014 were reviewed. Treatment delays were defined as the time from tissue diagnosis to definitive surgery, categorized as < 4, 4 to < 8, and ≥ 8 weeks. Primary outcomes were 5-year disease-free (DFS) and overall survival (OS). Statistical analysis included Kaplan-Meier curves and Cox regression models. A total of 408 patients were included (83.2% colon;15.8% rectal) with a mean follow-up of 58.4 months (SD29.9). Fourteen percent (14.0%) of patients underwent resection < 4 weeks, 40.0% 4 to < 8 weeks, and 46.1% ≥ 8 weeks. More rectal cancer patients had treatment delay ≥ 8 weeks compared with colonic tumors (69.8% vs. 41.4%, p < 0.001). Cumulative 5-year DFS and OS were similar between groups (p = 0.558; p = 0.572). After adjusting for confounders, surgical delays were not independently associated with DFS and...Continue Reading

References

Dec 1, 1975·Cancer·T MutoB C Morson
Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·S R Hamilton
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 30, 2003·The British Journal of Surgery·D C McMillanC S McArdle
May 14, 2004·The New England Journal of Medicine·UNKNOWN Clinical Outcomes of Surgical Therapy Study GroupDavid Ota
Sep 18, 2007·Diseases of the Colon and Rectum·Joe J Tjandra, Miranda K Y Chan
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndréAimery de Gramont
Dec 24, 2010·Diseases of the Colon and Rectum·Samantha HendrenArden M Morris
Jul 31, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jingbo WangFeng-Ming Spring Kong
Dec 12, 2012·Diseases of the Colon and Rectum·Karl MrakJörg Tschmelitsch
Oct 31, 2013·Annals of Surgery·Ryan P MerkowKarl Y Bilimoria
May 23, 2014·Annals of Surgical Oncology·Ramzi AmriDavid L Berger
Nov 19, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C HandforthJ Young
Jul 15, 2015·Diseases of the Colon and Rectum·Scott R SteeleUNKNOWN Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dec 15, 2015·JAMA Oncology·Richard J BleicherBrian L Egleston
Sep 14, 2016·Annals of Surgical Oncology·Hari NathanSandra L Wong
May 22, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J A FlemmingC M Booth
Oct 17, 2017·The Annals of Thoracic Surgery·Amelia W MaigaEric L Grogan
Nov 8, 2017·Diseases of the Colon and Rectum·Kerollos Nashat WanisMuriel Brackstone
Mar 14, 2018·International Journal of Surgery·Javier A CienfuegosJosé Luis Hernández Lizoáin
Mar 27, 2018·International Journal of Colorectal Disease·N J CurtisNader K Francis
Sep 27, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C Hangaard HansenI Gögenur
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C HandforthJ Young

❮ Previous
Next ❯

Citations

May 7, 2020·Current Opinion in Anaesthesiology·Enrico Maria MinnellaFrancesco Carli
Jul 2, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Scott C FligorMark P Callery
Mar 21, 2021·International Journal of Colorectal Disease·A K WarpsUNKNOWN Dutch ColoRectal Audit
Mar 14, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Thomas M WhittakerGethin L Williams
Apr 15, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter TschannIngmar Königsrainer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Frank E JohnsonRoldano Fossati
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
R RazikC J Swallow
© 2021 Meta ULC. All rights reserved