The impact of depression on health-related quality of life and wellbeing: identifying important dimensions and assessing their inclusion in multi-attribute utility instruments

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Lidia EngelCathrine Mihalopoulos

Abstract

Wellbeing measures have been proposed for inclusion in economic evaluation to measure the effect of depression and compensate for shortcomings of existing multi-attribute utility instruments (MAUIs). The aims of this study were to identify dimensions of health-related quality of life (HRQoL) and wellbeing that are most affected by depression and to examine the extent to which these are captured by MAUIs. Data were used from the Multi-Instrument Comparison study. Dimensions of HRQoL (SF-36v2 and AQoL-8D dimensions), capability wellbeing (ICECAP-A), and subjective wellbeing (including PWI, SWLS, and IHS) were identified that distinguished most individuals with depression from a healthy public. The extent to which these dimensions explain the content of five existing MAUIs (15D, AQoL-8D, EQ-5D-5L, HUI-3, and SF-6D) was examined using regression analyses. Additionally, the sensitivity of all MAUIs was also assessed towards depression-specific symptoms measured by DASS-21 and K-10. The sample consisted of 917 individuals with self-reported depression and 1760 healthy subjects. Dimensions that distinguished most individuals with depression from the healthy group (effect size > 2) included AQoL-8D coping, AQoL-8D happiness, AQoL-8D se...Continue Reading

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Citations

Dec 26, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Timea Mariann HelterJudit Simon
Dec 8, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·You-Shan FengInes Buchholz
Nov 3, 2020·PharmacoEconomics·Ron D Hays, Peter M Fayers
Jan 18, 2021·Journal of Psychosomatic Research·Sara Carrillo de Albornoz, Gang Chen
Apr 25, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nafsika Afentou, Philip Kinghorn
Oct 10, 2020·Journal of Psychiatric Research·Erito Marques de Souza FilhoJorge Amaral
Jun 9, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Joanna RostkowskaHenryk Skarzynski

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