The impact of diabetes and diabetes medications on bone health

Endocrine Reviews
Matthew P Gilbert, Richard E Pratley

Abstract

Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures despite increased body weight and normal or higher bone mineral density. The mechanisms by which T2DM increases skeletal fragility are unclear. It is likely that a combination of factors, including a greater risk of falling, regional osteopenia, and impaired bone quality, contributes to the increased fracture risk. Drugs for the treatment of T2DM may also impact on the risk for fractures. For example, thiazolidinediones accelerate bone loss and increase the risk of fractures, particularly in older women. In contrast, metformin and sulfonylureas do not appear to have a negative effect on bone health and may, in fact, protect against fragility fracture. Animal models indicate a potential role for incretin hormones in bone metabolism, but there are only limited data on the impact of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 agonists on bone health in humans. Animal models also have demonstrated a role for amylin in bone metabolism, but clinical trials in patients with type 1 diabetes with an amylin analog (pramlintide) have not shown a significant impact on bone metabolism. The effects of insulin treatment on fracture ri...Continue Reading

References

Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P V HauschkaP M Gallop
Jan 1, 1990·Hormone Research·J VerhaegheR Bouillon
Jul 1, 1989·Physiological Reviews·P V HauschkaC M Gundberg
Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Sep 4, 1980·The New England Journal of Medicine·H HeathC P Chu
Mar 15, 1995·Annals of Internal Medicine·P L van DaeleH A Pols
Feb 6, 1995·Biochemical and Biophysical Research Communications·J CornishI R Reid
Jul 29, 1998·Diabetes Research and Clinical Practice·U CakatayF Aral
Sep 24, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A K BormP P Naworth
Apr 5, 2000·The Journal of Clinical Investigation·N OgataH Kawaguchi
Jun 1, 2000·The Journal of Endocrinology·M N Horcajada-MolteniJ P Barlet
Jul 27, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M M Campos PastorA G García-Cervigón
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·J CornishI R Reid
Feb 7, 2001·The American Journal of Clinical Nutrition·T A RicciS A Shapses
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·A V SchwartzUNKNOWN Study of Osteoporotic Features Research Group
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M N Horcajada-MolteniJ P Barlet
Jun 26, 2001·Diabetes Care·K K NicodemusUNKNOWN Iowa Women's Health Study
Jun 26, 2001·Diabetes Care·R Q IversUNKNOWN Blue Mountains Eye Study
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Aug 13, 2002·Current Pharmaceutical Design·J Cornish, D Naot
Sep 21, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth J OttenbacherKyriakos S Markides
Feb 18, 2003·Journal of the American Geriatrics Society·Anne B NewmanUNKNOWN Health Aging And Body Composition Research Group
Jul 2, 2003·Regulatory Peptides·Kristine MortensenCathrine Orskov
Nov 8, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Bronský, R Průsa
Nov 25, 2003·The EMBO Journal·David G WinklerJohn A Latham

❮ Previous
Next ❯

Citations

Feb 18, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y LimM-I Kang
Mar 31, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E CavalierJ-J Body
Sep 9, 2016·Diabetes, Obesity & Metabolism·Robert G JosseUNKNOWN TECOS Study Group
May 2, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Laura C OrtinauPamela S Hinton
Mar 24, 2018·Clinical and Experimental Pharmacology & Physiology·Artur StolarczykAgnieszka Cudnoch-Jędrzejewska
Dec 14, 2017·Frontiers in Neurology·María Carolina Bermúdez ReyDaniel M Merfeld
Jan 1, 2019·Annals of Internal Medicine·Michael FralickElisabetta Patorno
Jul 27, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Daniel Wolverton, Melissa M Blair
Feb 18, 2019·Endocrine Connections·Ann-Kristin PickeMartina Rauner
Jun 21, 2019·Journal of Diabetes·Jian-Min LiuUNKNOWN Chinese Society of Osteoporosis and Bone Mineral Research, the Chinese Society of Endocrinology, Chinese Diabetes Society, C
Apr 30, 2019·Journal of Cellular Physiology·Yanan KongYu Zhao
Sep 27, 2019·Annals of the New York Academy of Sciences·Fawzy Ali Saad
Aug 9, 2019·The Journal of Bone and Joint Surgery. American Volume·Shasta HendersonFrancis Y Lee
Aug 31, 2019·Journal of Orthopaedic Trauma·Yasmine ElamirRichard S Yoon
Jan 12, 2020·Journal of Physiology and Biochemistry·Samuel Álvarez-AlmazánJessica Elena Mendieta-Wejebe
Aug 11, 2015·The Journal of Clinical Endocrinology and Metabolism·Tianpeng ZhengShenghua Qin
Nov 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Emma HamiltonTimothy M E Davis
Sep 6, 2017·The Journal of Pharmacy and Pharmacology·Daphne P L Lin, Crispin R Dass
Oct 28, 2017·Diabetology & Metabolic Syndrome·Claudia Pinheiro SanchesFellype de Carvalho Barreto
Jan 10, 2017·Climacteric : the Journal of the International Menopause Society·C A Stuenkel
Jun 21, 2017·Scientific Reports·Eladio Losada-GrandeDaniel Prieto-Alhambra
Jul 8, 2018·Acta Diabetologica·Alessia ValentiniAldo Bertoli
Mar 19, 2019·Frontiers in Endocrinology·Consolato SergiSong-Mei Liu
Aug 17, 2019·Frontiers in Endocrinology·Greisa VilaGünter K Stalla
Jun 5, 2018·Journal of Osteoporosis·Nahid J RianonSusan P Fisher-Hoch
Oct 13, 2017·Diabetology & Metabolic Syndrome·A G D ViannaF C Barreto
Jul 4, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L T Ho-PhamT V Nguyen
Oct 28, 2019·Perspectives in Clinical Research·Jeffrey Pradeep RajRajkumar S Amaravati
Jan 4, 2017·International Journal of Endocrinology·Giuseppina T RussoDomenico Cucinotta
Sep 17, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D LeslieL M Lix
Feb 10, 2017·Calcified Tissue International·Andrea PalermoNicola Napoli
Jun 4, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E LosadaD Prieto-Alhambra
Jul 22, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A K NordklintP Eiken
Aug 7, 2019·Cardiovascular Diabetology·Aaron Y KlugerPeter A McCullough
Oct 27, 2020·Aging Clinical and Experimental Research·Yujia TaoZhen Zhang
Nov 29, 2020·Current Diabetes Reports·Hae Sang Lee, Jin Soon Hwang
Jan 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Takayoshi SasakoTakashi Kadowaki

❮ Previous
Next ❯

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