The impact of diabetes on depression treatment outcomes

General Hospital Psychiatry
Charlene BryanStephen R Wisniewski

Abstract

Individuals with diabetes mellitus (DM) are two to four times more likely to be diagnosed with major depressive disorder (MDD). However, few controlled studies have examined the impact of DM on the treatment of MDD. Understanding the effect of DM on depressed patients could provide valuable clinical information toward adjusting current treatment modalities to produce a more effective treatment for depressed patients with DM. This study was conducted using an evaluable sample of 2876 outpatient participants enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Sociodemographic and clinical characteristics and treatment characteristics with the selective serotonin reuptake inhibitor (SSRI) citalopram, as well as remission rates for MDD and time to remission, were compared between participants with DM and participants without DM. The odds of remission were lower in participants with DM than in those without DM prior to adjustment [odds ratio (OR)=0.68; 95% confidence interval (95% CI)=(0.49, 0.94); P=.0184]. These differences were no longer present after adjustment [OR=0.92; 95% CI=(0.64, 1.32); P=.6399]. Participants with DM reported fewer side effects than participants without DM despite similar dosing. D...Continue Reading

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Citations

Oct 18, 2011·Current Psychiatry Reports·Leonard E Egede, Clara E Dismuke
Jun 4, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·K RådholmC J Östgren
Oct 18, 2011·General Hospital Psychiatry·Kevin Brian KerberA John Rush
Aug 26, 2015·Journal of Evaluation in Clinical Practice·Kurt AngstmanGregory L Angstman
Jan 3, 2013·Primary Care Diabetes·Norbert HermannsFrank Snoek
Jun 13, 2015·Journal of Affective Disorders·Raoul BelzeauxUNKNOWN French Advanced Centers of Expertise for Bipolar Disorders Collaborators
Jan 9, 2015·Journal of Affective Disorders·Mark A FerroMichael H Boyle
Sep 21, 2013·Journal of Affective Disorders·Raoul BelzeauxUNKNOWN Fondamental Academic Centers of Expertise for Bipolar Disorders (FACE-BD) collaborators
Oct 17, 2015·British Journal of Pharmacology·Juliane ZemdegsBruno P Guiard
Sep 6, 2017·PloS One·Nadia CorréardUNKNOWN FACE-BD collaborators
Feb 20, 2021·Journal of Affective Disorders·Julia-Lou ConsoloniUNKNOWN Groupe FACE-BD

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