The Impact of Diabetic Conditions and AGE/RAGE Signaling on Cardiac Fibroblast Migration

Frontiers in Cell and Developmental Biology
Stephanie D BurrJames A Stewart Jr

Abstract

Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle (LV), which is thought to occur, in part, by increased AGE/RAGE signaling inducing fibroblast differentiation. Advanced glycated end-products (AGEs) accumulate within the body over time, and under hyperglycemic conditions, the formation and accumulation of AGEs is accelerated. AGEs exert their effect by binding to their receptor (RAGE) and can induce myofibroblast differentiation, leading to increased cell migration. Previous studies have focused on fibroblast migration during wound healing, in which diabetics have impaired fibroblast migration compared to healthy individuals. However, the impact of diabetic conditions as well as AGE/RAGE signaling has not been extensively studied in cardiac fibroblasts. Therefore, the goal of this study was to determine how the AGE/RAGE signaling pathway impacts cell migration in non-diabetic and diabetic cardiac fibroblasts. Cardiac fibroblasts were isolated from non-diabetic and diabetic mice with and without functional RAGE and used to perform a migration assay. Cardiac fibroblasts were plated on plastic, non-diabetic, or diabetic collagen, and when confluency was reache...Continue Reading

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Citations

Jun 25, 2020·Toxins·Regiane Stafim da CunhaAndréa Emilia Marques Stinghen
Mar 1, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alfredo RedondoEzequiel Álvarez
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Lingling JiangZhonghui Liu

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Methods Mentioned

BETA
GTPases
PCR
genotyping
Assay
light microscopy
PASR
GTPase

Software Mentioned

Image J
Adobe Photoshop Elements

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