The impact of diclofenac and ibuprofen on biofilm formation on the surface of polypropylene mesh

Hernia : the Journal of Hernias and Abdominal Wall Surgery
Adrian ReślińskiKatarzyna Głowacka

Abstract

The difficulties related to treatment of deep surgical site infection involve formation of biofilm on the surface of synthetic material. It is considered that in treatment of infections involving formation of biofilm, concomitant therapy shall be applied covering anti-inflammatory drugs. The purpose of the work was to assess the impact of diclofenac and ibuprofen on bacterial biofilm formation on the surface of monofilament polypropylene mesh. The study involved 70 strains of Staphylococcus aureus and 70 strains of Escherichia coli isolated from different patients and those which differ with chromosomal DNA pattern within the species. The assessment of the impact of non-steroidal anti-inflammatory drugs (NSAIDs) on biofilm formation was carried out with the use of qualitative method (TTC reduction), quantitative (tenfold serial dilution) and with the use of scanning electron microscope (SEM). In the qualitative assessment, after incubation in the medium containing NSAIDs statistically significant growth of S. aureus strain amount and E. coli which poorly make up biofilm was stated. Quantitative examination indicated characteristic decrease of the number of colony forming units in 1 ml of the suspension isolated from bacterial b...Continue Reading

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Citations

Feb 21, 2016·Pharmacology & Therapeutics·Suzana M RibeiroOctávio L Franco
Jul 17, 2016·American Journal of Surgery·José Bueno-LledóJosé I Hernández
Jan 10, 2018·Antimicrobial Agents and Chemotherapy·Parth N ShahCarolyn L Cannon
Jun 26, 2015·Advanced Healthcare Materials·Olivier GuillaumeAlexander Petter-Puchner
Sep 1, 2018·Hernia : the Journal of Hernias and Abdominal Wall Surgery·O GuillaumeA Petter Puchner
Jul 19, 2020·Environmental Science and Pollution Research International·Peter McClean, William Ross Hunter
May 27, 2021·BMJ Open·Dora Yesenia ValenciaKarl Krupp

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Statistica
NSS
StatSoft

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