The impact of disease duration on quality of life in children with nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
David T SelewskiDebbie S Gipson

Abstract

The Patient Reported Outcomes Measurement Information System (PROMIS) II is a prospective study that evaluates patient reported outcomes in pediatric chronic diseases as a measure of health-related quality of life (HRQOL). We have evaluated the influence of disease duration on HRQOL and, for the first time, compared the findings of the PROMIS measures to those of the PedsQL™ 4.0 Generic Scales (PedsQL) from the PROMIS II nephrotic syndrome (NS) longitudinal cohort. This was a prospective study in which 127 children (age range 8-17 years) with active NS from 14 centers were enrolled. Children with active NS defined as the presence of nephrotic range proteinuria (>2+ urinalysis and edema or urine protein/creatinine ratio >2 g/g) were eligible. Comparisons were made between children with prevalent (N = 67) and incident (N = 60) disease at the study enrollment visit. The PROMIS scores were worse in prevalent patients in the domains of peer relationship (p = 0.01) and pain interference (p < 0.01). The PedsQL showed worse scores in prevalent patients for social functioning (p < 0.01) and school functioning (p = 0.03). Multivariable analyses showed that prevalent patients had worse scores in PROMIS pain interference (p = 0.02) and Ped...Continue Reading

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Citations

Jun 5, 2016·Clinical Journal of the American Society of Nephrology : CJASN·David T SelewskiDebbie S Gipson
Aug 5, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M Hodson, Jonathan C Craig
Sep 9, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bryce B ReeveDarren A DeWalt
Jul 17, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shawn KhullarRulan S Parekh
May 2, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Pietro A Canetta, Andrew S Bomback
Feb 6, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Riham EidNashwa Hamdy
Nov 21, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mahmoud Kallash, John D Mahan
May 8, 2020·Complementary Therapies in Clinical Practice·Joel AlcantaraJunjoe Alcantara
Mar 23, 2019·Kidney International·Pietro A CanettaUNKNOWN CureGN Consortium
Nov 14, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Laura H MarianiUNKNOWN CureGN Consortium

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