The impact of diurnal variation of PSA on timing of measurement in prostate biopsy

The Prostate
Hakkı Uzun, Medeni Arpa

Abstract

Prostate-specific antigen (PSA) synthesis is related to testosterone, which has a diurnal rhythm. PSA might have a diurnal variation and the timing of measurement could change the clinical practice for prostate biopsy. Male patients complaining of lower urinary tract symptoms (group 1) and diagnosed with prostate cancer (group 2) were recruited into the study. Morning fasting blood samples were withdrawn between 9.00 and 11.00 am for the determination of biochemical parameters, PSA (PSA1), total testosterone (T1), and estradiol (E1) levels. In the afternoon, between 15.00 and 15.30 pm, blood samples were again obtained from the same participants at the same day and the serum concentration of PSA (PSA2), total testosterone (T2), and estradiol (E2) were measured. A total of 160 and 30 patients were enrolled in groups 1 and 2, respectively. One hundred forty (87.5%) and 26 (86.6%) patients had a decrease in the PSA levels when measured in the afternoon. The Wilcoxon signed-rank test determined a statistically significant difference between the PSA levels measured in the morning and in the afternoon in each group. An analysis of covariance test revealed no statistically significant difference in PSA concentration between the groups...Continue Reading

References

Jan 1, 1982·Annals of the New York Academy of Sciences·A W Bruce, D E Mahan
Jun 26, 1981·JAMA : the Journal of the American Medical Association·W D BrenckmanF Sedor
Sep 1, 1994·International Journal of Urology : Official Journal of the Japanese Urological Association·S AkimotoJ Shimazaki
Nov 28, 2002·International Urology and Nephrology·A TekinH Ozen
Sep 12, 2015·Current Medical Research and Opinion·E David CrawfordDavid Muram

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