Abstract
Docetaxel is a widely used cytotoxic agent. This study evaluates the impact of docetaxel toxicities on patient's health-related quality of life (QoL). We conducted a multicenter, prospective, non-interventional trial, in which the QoL was assessed using the EORTC QLQ-C30 questionnaires at baseline and every 4 weeks up to 40 weeks in patients receiving a docetaxel-based chemotherapy for metastatic disease. Treatment-related adverse events were correlated with the corresponding QoL scores. Uni- and multivariate analyses were applied. From January 2008 to June 2011, a total of 2659 patients were included. The majority of patients (48.1%) had prostate cancer, followed by breast (17.1%) and non-small-cell-lung cancer (15.8%). Patients received a median of 5 docetaxel cycles with the median dose of 75 mg/m(2). The presence of grade 3/4 diarrhea showed the strongest effect on global health status/QoL average scores (50.91 versus 33.06), followed by vomiting (50.91 versus 35.17), dyspnea (50.94 versus 35.81), mucositis/stomatitis (50.88 versus 36.41), nausea (50.91 versus 36.68), infection (50.90 versus 37.14), fatigue (50.90 versus 43.82) and anemia (50.91 versus 41.03), P < 0.05 for all comparisons. Grade 3/4 leukopenia/neutropenia, ...Continue Reading
References
Oct 13, 2004·The Oncologist·John D Hainsworth
Jan 29, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Barry V FortnerBrad S Stolshek
Jul 12, 2005·BMC Nursing·Barry V FortnerLee S Schwartzberg
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemUNKNOWN V325 Study Group
May 29, 2007·Journal of Pain and Symptom Management·Digant GuptaJames F Grutsch
Aug 1, 2007·The Oncologist·Maarten HofmanGary R Morrow
Jul 11, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lynne I WagnerDavid Cella
Jan 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carolyn C GotayFabio Efficace
Mar 7, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Petra FeyerMonika Behrens
Aug 22, 2009·The Lancet Oncology·Chantal QuintenUNKNOWN EORTC Clinical Groups
Sep 30, 2010·Health and Quality of Life Outcomes·Marianne Voll-AanerudBenedicte Leynaert
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff A SloanPing Yang
Aug 23, 2012·Health and Quality of Life Outcomes·Sarah WilkeMartijn A Spruit
Jun 1, 2013·The European Respiratory Journal·Christer JansonPeter Burney
Citations
Jan 10, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S-E Al-BatranH Wilke
Aug 21, 2015·Expert Opinion on Pharmacotherapy·Peggy L LinEric Q Wu
Apr 8, 2016·The Breast : Official Journal of the European Society of Mastology·Lukas SchwentnerVisnja Fink
Jul 16, 2016·European Urology·Che-Kai TsaoWilliam K Oh
Nov 12, 2015·Therapeutic Advances in Gastroenterology·Kate YoungIan Chau
Jun 7, 2017·Physiological Reports·Thomas ChaillouJohanna T Lanner
May 16, 2018·The British Journal of Radiology·Harshad R KulkarniRichard P Baum
May 8, 2018·Oncology Research and Treatment·Karin BergerHelmut Ostermann
Aug 4, 2018·Acta Oncologica·Are KristensenBjørn Henning Grønberg
Jan 29, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mark de MolJoachim G Aerts
May 9, 2019·European Journal of Cancer Care·Huang-Tz OuWei-Tse Fang
Jul 16, 2019·British Journal of Cancer·Elisabetta MunzonePaolo Veronesi
Dec 22, 2019·Cancers·Doo Yong ChungKang Su Cho
Apr 14, 2016·Cancer Nursing·Maria Fernanda Barbirato da Mata TiezziLúcia Alves Silva Lara
Oct 18, 2016·The Cancer Journal·Min Yuen Teo, Michael J Morris
Mar 1, 2019·Breast Cancer Research : BCR·Joanne MortimerMohammad Jahanzeb
Apr 22, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·A R T BerginP de Souza
Dec 7, 2018·Frontiers in Oncology·Saskia SpaichMarc Sütterlin
May 20, 2020·BMC Cancer·Mark de MolBrenda den Oudsten
Mar 28, 2017·Cancer Chemotherapy and Pharmacology·JoungSoon JangJong Wook Shin
Jun 23, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Beate RauUNKNOWN Peritoneum Surface Oncology Group and members of the StuDoQ|Peritoneum Registry of the German Society for General and Viscer
Sep 26, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sharon Odeo, Amsalu Degu
Jan 12, 2021·Bulletin du cancer·Sonia Ben NasrAbderrazek Haddaoui