The Impact of Docosahexaenoic Acid on Alzheimer's Disease: Is There a Role of the Blood-Brain Barrier?

Current Clinical Pharmacology
Yijun PanJoseph A Nicolazzo

Abstract

There currently is no cure or established preventative treatment for Alzheimer's disease (AD). Considering the increasing aging population and the subsequent high prevalence of AD worldwide, identifying a cost-effective way to prevent AD is an essential unmet medical need. Relative to healthy human brain samples, postmortem AD brain samples have been shown to exhibit lower docosahexaenoic acid (DHA) levels, an essential polyunsaturated fatty acid required for normal neuronal function. However, findings from different studies are controversial and it is not clear whether this alteration in DHA brain levels is a cause or consequence of AD. Animal studies have also demonstrated that administration of DHA can alleviate the underlying pathophysiology of AD, including but not limited to amyloid pathology, tau pathology, and neuroinflammation. Moreover, DHA has been suggested to exert cognitive-enhancing effects and epidemiological studies have suggested that regular consumption of fish or omega-3 fatty acid enriched diets can attenuate the cognitive decline in AD and/or lower the risk of developing AD. However, the beneficial effects of DHA in AD have not been clearly demonstrated by current human randomised-control trials. In additi...Continue Reading

Citations

May 22, 2018·Journal of Alzheimer's Disease : JAD·Zhiyou CaiQin Li
Feb 11, 2019·Archives of Pharmacal Research·Doo Sin Jo, Dong-Hyung Cho
Jun 26, 2020·Frontiers in Physiology·Hannah ChewAlfred N Fonteh
Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Brenda Yasie LeeZoya Leonenko
Sep 13, 2020·Experimental & Molecular Medicine·Doo Sin JoDong-Hyung Cho
Oct 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marta OliveiraSimone Morais
Apr 4, 2021·International Journal of Molecular Sciences·Manon LeclercFrédéric Calon
May 1, 2021·Nutrients·Nicholas G NorwitzRichard S Isaacson
Jun 15, 2021·Molecular Omics·Seul Kee ByeonAkhilesh Pandey
Oct 13, 2015·Molecular Pharmaceutics·Yijun PanJoseph A Nicolazzo
Aug 28, 2021·Biomedicines·Irina KurokinMarcus Otto Walter Grimm

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