The impact of dopamine on hemodynamics, oxygen metabolism, and cerebral resuscitation after restoration of spontaneous circulation in pigs

The Journal of Emergency Medicine
Zhaoxia LiuGuichen Zhang

Abstract

Restoration of spontaneous circulation after cardiopulmonary resuscitation in cardiac arrest patients does not always signal a completely successful outcome. Functional deficiencies of the nervous system are found in many survivors of cardiac arrest. To study the effects of dopamine-induced elevated blood pressure on the hemodynamics, oxygen metabolism, and cerebral resuscitation in different perfusion conditions in a resuscitated animal model. There were 18 pigs included in the study. Ventricular fibrillation (VF) was induced with a programmed electrical stimulation device. After 4 min of untreated ventricular fibrillation followed by 9 min of CPR, 12 animals were resuscitated successfully, and were then randomly assigned to either the study group (dopamine group) or the control group (normal perfusion group). All animals in the two groups received normal saline through continuous intravenous guttae for 4 h at a rate of 15 mL/kg/h. In the study group, dopamine was added to raise the animals' blood pressure. Four hours of intensive monitoring was performed for all study animals. Finally, 24-h evaluation of neurological function was conducted in surviving animals in accordance with the standard of the Cerebral Performance Catego...Continue Reading

References

Apr 1, 1977·The Annals of Thoracic Surgery·G MerinJ B Borman
Aug 1, 1989·Critical Care Medicine·K B KernG A Ewy
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·C SundgreenJ Aldershvile
Sep 26, 2001·Archives of Internal Medicine·A ZeinerA N Laggner
Feb 16, 2002·Cardiology Clinics·Karl B Kern
Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Isao TakamatsuTomohiro Okuda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.