PMID: 8393273Jun 1, 1993Paper

The impact of dose intensity of standard chemotherapy regimens in extensive stage small cell lung cancer

American Journal of Clinical Oncology
R G SheehanE P Frenkel

Abstract

Oncologists often attenuate the doses of chemotherapy drugs in published standard regimens to avoid toxicity. The impact on survival of this practice in patients with extensive stage small cell lung cancer (SCLC) is uncertain. We have compared the outcome of 85 patients treated with a program of cyclophosphamide, doxorubicin, and vincristine to a group of 37 patients treated with conventional regimens of higher dose intensity. The two groups of patients were shown to be equivalent in terms of staging evaluation, response and survival criteria, and pretreatment prognostic factors. The latter was confirmed by applying a published prognostic algorithm. Complete response rates (38% vs 14%) were significantly better with the higher intensity regimens (p = .003). The median survival (39 vs 26 weeks), 1 year survival (32% vs 12%), and overall survival (p = .002) were superior with the full-dose intensity protocols. Myelotoxicity was also greater with the contemporary treatments. Cox proportional hazards analysis, correcting for pretreatment prognostic variables, confirmed the improved survival with conventional doses of therapy (p = .0055). These results support the concept that full-dose intensity chemotherapy provides survival benef...Continue Reading

Citations

Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erika BuchholzPeter Drings
Jan 1, 2008·PET Clinics·Lale Kostakoglu
Jul 1, 1997·Cancer Treatment Reviews·A L Thomas, P J Woll
Feb 24, 2005·Seminars in Oncology·Jeffrey Crawford
Jun 7, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jeffrey CrawfordGary H Lyman
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J WollR Pettengell
Apr 28, 2017·Science Translational Medicine·Shenghui HeNorman E Sharpless

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