Abstract
This study correlated overall serum IgA levels in pretransplant (preTx) sera with graft survival. IgA levels, determined by nephelometry, were normally distributed, with a mean level of 255 +/- 139 mg/dl and a median of 234 mg/dl in 631 adult primary kidney allograft recipients and a mean level of 213 +/- 123 mg/dl with a median of 196 mg/dl for 100 retransplant recipients. Improved 3-year survival was associated with a high preTx IgA serum level in primary recipients (Kaplan-Meier analysis, P = 0.01), but not in retransplant patients. After stratifying by race, IgA correlated with graft survival in Caucasian, Hispanic, and "other" (Middle Eastern, Indian subcontinent, and Asian) primary recipients (P < or = 0.04), but not in African Americans. Higher survival rates were not associated with IgA in primary recipients stratified for rejection episodes, blood transfusions, or HLA-DR mismatches. Graft survival was improved in patients with > 2 HLA-AB mismatches and serum IgA above the median. PreTx IgA level and IgA alpha-HLA activity were significantly associated in preTx sera of primary renal allograft recipients (chi 2 = 7.145, P = 0.01), although only 9% (12/133) of sera tested displayed IgA anti-HLA class I reactivity. Thus, e...Continue Reading
References
Nov 1, 1978·Transplantation·A WeissF W Fitch
Oct 1, 1992·Transplantation·C SüsalG Opelz
Jun 1, 1991·Kidney International·P A Crowley-NowickS Jackson
Feb 1, 1992·Transplantation·B D KahanC T Van Buren
May 1, 1991·Human Immunology·D PhelanT Mohanakumar
Feb 1, 1991·Transplantation·R H KermanB D Kahan
Nov 1, 1988·Transplantation·B D Kahan, J Grevel
Dec 1, 1985·Transplantation·R H KermanB D Kahan
Nov 1, 1969·Transplantation·G A VoisinC Bernard
Jul 1, 1982·Transplantation·B D KahanR H Kerman
Jan 1, 1980·Transplantation·W C Davis, I F McKenzie
Jan 1, 1980·Immunological Reviews·D C Parker
Aug 1, 1993·Transplantation·B ChauhanT Mohanakumar
Apr 1, 1993·Immunology Letters·C SüsalG Opelz
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·C SüsalG Opelz
Oct 1, 1993·Journal of Autoimmunity·C SüsalG Opelz
Nov 1, 1993·Transplantation·R H KermanB D Kahan
Jul 1, 1993·Transplantation·P KokaE Lim
May 1, 1993·Transplantation·E C LimP I Terasaki
Sep 1, 1995·Human Immunology·R BuelowH Grosse-Wilde
Citations
Dec 5, 1998·Transplantation Proceedings·M S KimK Park
Dec 1, 1999·Transplantation Proceedings·A MorgunM Gerbase-DeLima
Jul 17, 2010·Clinical Journal of the American Society of Nephrology : CJASN·M Colleen HastingsRobert J Wyatt
May 3, 2011·Journal of Immunological Methods·Hooi Sian Eng, Mary S Leffell
Jan 3, 2013·International Journal of Immunogenetics·M-L ArnoldB M Spriewald
Jun 4, 2015·Transplantation Proceedings·M A AmirzargarG Solgi
Jun 3, 2000·Transplantation·R S WarraichM H Yacoub
Mar 30, 2019·PloS One·Frank-Peter TillmannLars Christian Rump
Apr 27, 2020·Clinical Transplantation·Zane C GiffenJorge Ortiz
Jun 26, 1999·Clinical Transplantation·M BunkeB Ketel
Mar 27, 2018·International Journal of Immunogenetics·M-L ArnoldB M Spriewald