The impact of ERα action on muscle metabolism and insulin sensitivity - Strong enough for a man, made for a woman

Molecular Metabolism
Andrea L HevenerVicent Ribas

Abstract

The incidence of chronic disease is elevated in women after menopause. Natural variation in muscle expression of the estrogen receptor (ER)α is inversely associated with plasma insulin and adiposity. Moreover, reduced muscle ERα expression levels are observed in women and animals presenting clinical features of the metabolic syndrome (MetSyn). Considering that metabolic dysfunction impacts nearly a quarter of the U.S. adult population and elevates chronic disease risk including type 2 diabetes, heart disease, and certain cancers, treatment strategies to combat metabolic dysfunction and associated pathologies are desperately needed. This review will provide evidence supporting a critical and protective role for skeletal muscle ERα in the regulation of metabolic homeostasis and insulin sensitivity, and propose novel ERα targets involved in the maintenance of metabolic health. Studies identifying ERα-regulated pathways essential for disease prevention will lay the important foundation for the rational design of novel therapeutics to improve the metabolic health of women while limiting secondary complications that have plagued traditional hormone replacement interventions.

Citations

Sep 3, 2019·Frontiers in Endocrinology·Renée Ventura-ClapierAnne Garnier
Nov 12, 2020·Nature Reviews. Endocrinology·Gijs H GoossensEllen E Blaak
Feb 1, 2020·Redox Biology·Carolyn M Klinge
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·Kadden H KothmannAnnie E Newell-Fugate
May 1, 2021·International Journal of Molecular Sciences·Manuela MoriggiDaniele Capitanio
Aug 23, 2021·The Journal of Biological Chemistry·Yaxin ZhaoJoseph L Napoli

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Methods Mentioned

BETA
hormone replacement therapy
nuclear translocation
dissection
immunoprecipitation

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