The impact of ezetimibe on endothelial function and other markers of cardiovascular risk.

The Annals of Pharmacotherapy
Almasa BassCraig R Lee

Abstract

To review the published literature characterizing the impact of ezetimibe-containing lipid-lowering regimens on endothelial function and other markers of cardiovascular risk and discuss the potential relevance of these effects to the clinical benefit of ezetimibe. A MEDLINE search (2000-August 2009) was completed using the key words ezetimibe, statins, endothelial function, flow-mediated dilation, pleiotropic, and inflammation to identify relevant literature. Bibliographies of identified literature were reviewed for additional references. All clinical studies published in English that evaluated the effect of ezetimibe on ancillary endpoints of cardiovascular disease risk, including endothelial function, inflammation, thrombosis, and oxidative stress, were evaluated. Recent studies in patients with coronary artery disease (CAD), heart failure, and hypercholesterolemia have demonstrated that treatment with ezetimibe for 4-12 weeks elicits no improvement of endothelial function or other measures of cardiovascular disease risk. In contrast, other studies have reported that ezetimibe improves endothelial function in certain patient populations, including those with rheumatoid arthritis, CAD with type 2 diabetes, and metabolic syndro...Continue Reading

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Citations

Mar 19, 2014·Heart·Julian P Halcox, Craig J Currie
Dec 4, 2010·Vascular Health and Risk Management·Ian Hamilton-CraigStan Woodhouse
Sep 29, 2011·International Journal of Clinical Practice·A S Wierzbicki
Oct 2, 2015·Indian Journal of Endocrinology and Metabolism·Narasaraju KavalipatiHardik Vasnawala
Apr 2, 2011·Expert Review of Cardiovascular Therapy·Nkechinyere Ijioma, Jennifer G Robinson
Oct 26, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Kazuhiko KotaniNobuyuki Taniguchi
Sep 5, 2019·Current Medicinal Chemistry·Bozidarka ZaricEsma R Isenovic
Jul 15, 2016·Deutsches Ärzteblatt International·Barbara NußbaumerGerald Gartlehner

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