PMID: 11316330Apr 24, 2001Paper

The impact of fetal size and length of gestation on 6-sulphatoxymelatonin excretion in adult life

Journal of Pineal Research
D J KennawayD I Phillips

Abstract

Recent studies have shown that intrauterine growth retardation or fetal distress in human infants is associated with a pronounced reduction in melatonin secretion during the first 3 months of life. It is not known whether these associations persist beyond infancy. We have therefore examined the relationship between birthsize and melatonin secretion in 159 men and women aged 20, born in Adelaide, South Australia. Melatonin secretion was estimated by analysing the overnight urinary excretion of 6-sulphatoxymelatonin. The overnight excretion ranged from 1.7 to 128.9 nmoles/subject, was higher in women than in men (46.5 vs 34.1 nmoles, P = 0.003) and was significantly negatively correlated with the body mass index (P = 0.006). Excretion correlated with both birthweight and ponderal index at birth (P = 0.04 and P = 0.01 respectively after adjustment for gestational age) and also fell with increased duration of gestation (P = 0.007). The effects of adult body mass index added to that of low birthweight in predicting 6-sulphatoxymelatonin excretion. These data suggest that urinary 6-sulphatoxymelatonin excretion was impaired in adults who were growth restricted prenatally or were delivered after 40 weeks gestation.

Citations

Jan 20, 2004·Molecular Genetics and Metabolism·Grace Wang YingEdmund Jon Deoon Lee
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·David J Kennaway
Sep 1, 1999·Clinical Endocrinology·D E FlanaganD I Phillips
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·J A JacksonS A Petersen
May 12, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Salvatore AversaEloisa Gitto
Feb 28, 2006·Journal of Pineal Research·Hugo L FideleffDaniel P Cardinali
Dec 5, 2008·Journal of Pineal Research·Eloisa GittoRussel J Reiter
Jan 10, 2002·Seminars in Perinatology·M Serón-FerréG J Valenzuela
Jul 22, 2008·Diabetes & Metabolism·P-J GuillausseauJ-P Kevorkian
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Rebecca Simmons
Jun 28, 2005·Journal of the Society for Gynecologic Investigation·Janna L MorrisonK Wayne Riggs
Nov 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tamara J VarcoeDavid J Kennaway
Nov 23, 2017·Sleep·Stephanie R YiallourouRosemary S C Horne

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