PMID: 7992347Sep 1, 1994Paper

The impact of five years of annual ivermectin treatment on skin microfilarial loads in the onchocerciasis focus of Asubende, Ghana

Transactions of the Royal Society of Tropical Medicine and Hygiene
Edoh S AlleyE M Samba

Abstract

Following the registration of ivermectin (Mectizan) for human use in the treatment of onchocerciasis, in 1987 the Onchocerciasis Control Programme in West Africa (OCP) begun a series of trials in order to determine the safety of the drug when used on a large scale and its potential for morbidity control. This paper reports the changes in skin microfilarial loads during the first 5 years of annual treatment in the holoendemic focus of Asubende in Ghana, which was the largest trial area and which also had the longest series of follow-up surveys. The general observed pattern was a marked reduction of microfilarial loads shortly after each treatment followed by a steady repopulation of the skin until a subsequent treatment round. The overall reduction of microfilarial loads observed between the base line survey and one year after the last treatment was 90% for the total population examined and over 93% for a cohort which received the drug at all 5 treatment rounds. In contrast, there was only a very gradual decrease in the prevalence of infection in the population after subsequent treatments. The study further emphasizes that even a single treatment with ivermectin has a significant medium-term impact on microfilarial loads. Microf...Continue Reading

References

Nov 1, 1977·The Journal of Small Animal Practice·R W ElseC Potter
Feb 1, 1992·The American Journal of Tropical Medicine and Hygiene·B O DukeB Munoz
Jul 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·J A WhitworthD W Taylor
Mar 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·K Y DadzieG De Sole
Feb 1, 1991·The Journal of Infectious Diseases·B M GreeneH R Taylor
Jan 1, 1990·Computer Methods and Programs in Biomedicine·A P PlaisierE S Alley
Jan 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·K Y DadzieG de Sole
Oct 1, 1989·The American Journal of Tropical Medicine and Hygiene·H R Taylor, B M Greene
May 1, 1992·Parasitology Today·H Schulz-KeyW H Hoffmann

❮ Previous
Next ❯

Citations

Jun 20, 2000·Parasitology Today·A P PlaisierJ D Habbema
Jul 28, 2004·Parasitology Today·D H Molyneux, J B Davies
Nov 20, 2004·Nature Reviews. Microbiology·Satoshi Omura, Andy Crump
Apr 7, 2011·PLoS Neglected Tropical Diseases·Mike Y Osei-AtweneboanaRoger K Prichard
Jun 27, 1998·Lancet·G Burnham
Jan 18, 2007·Annals of Tropical Medicine and Parasitology·B Thylefors, M Alleman
Jan 19, 1999·Tropical Medicine & International Health : TM & IH·W R BriegerJ H Remme
May 13, 2008·The Lancet Infectious Diseases·María-Gloria BasáñezMichel Boussinesq
Apr 14, 2004·Tropical Medicine & International Health : TM & IH·James M Tielsch, Arlyne Beeche
Apr 13, 2006·Medical and Veterinary Entomology·A Krueger
Mar 24, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kwadwo K FrempongMaría-Gloria Basáñez
Sep 30, 2006·Molecular and Biochemical Parasitology·J K L EngR K Prichard
Apr 22, 2015·PLoS Neglected Tropical Diseases·Poppy H L LambertonMaría-Gloria Basañez
Jul 14, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Peter H AdlerRory J Post
Jun 1, 2006·Advances in Parasitology·Boakye A Boatin, Frank O Richards
Feb 6, 2013·PLoS Neglected Tropical Diseases·Luc E CoffengUche V Amazigo
May 2, 2013·PLoS Neglected Tropical Diseases·Hugo C TurnerMaría-Gloria Basáñez
Jul 28, 2020·Expert Review of Anti-infective Therapy·Philip MiltonMaría-Gloria Basáñez
Dec 1, 1996·Tropical Medicine & International Health : TM & IH·J A WhitworthM D Downham
Jan 4, 2021·Parasites & Vectors·Nana-Kwadwo BiritwumJohn Owusu Gyapong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

The Journal of Infectious Diseases
M PacquéH R Taylor
Transactions of the Royal Society of Tropical Medicine and Hygiene
R H GuderianP J Cooper
© 2021 Meta ULC. All rights reserved