The impact of gastroesophageal reflux disease on health-related quality of life

The American Journal of Medicine
D A RevickiS Sorensen

Abstract

Gastroesophageal reflux disease (GERD) affects health-related quality of life. We enrolled 533 adults with a history of heartburn symptoms for at least 6 months of moderate to severe heartburn in 4 of the 7 days before study entry. Patients were treated with ranitidine 150 mg twice a day for 6 weeks and Gelusil antacid tablets as needed. We measured physician-rated symptoms and the Medical Outcomes Study short-form 36 (SF-36) Health Survey at baseline and after 6 weeks of treatment. Baseline results were compared with normative data for the US population and for patients with selected chronic diseases. Treatment response was defined as no episode of moderate to severe heartburn for 7 days. Statistical significance was set at P <0.001. GERD patients reported significantly worse scores on all 8 SF-36 scales, physical function and well-being, and emotional well-being compared with the general population. Patients with GERD reported worse emotional well-being than patients with diabetes or hypertension. Treatment responders demonstrated significantly less pain and better physical function, social function, vitality, and emotional well-being compared with nonresponders. Patients with GERD experience decrements in health-related qual...Continue Reading

References

Nov 1, 1976·The American Journal of Digestive Diseases·O T NebelD O Castell
Oct 1, 1984·The American Journal of Cardiology·N K WengerJ Elinson
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·I Wiklund
Sep 1, 1994·Mayo Clinic Proceedings·K R DeVault, D O Castell
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·E Dimenäs
Aug 1, 1993·Scandinavian Journal of Gastroenterology·E DimenäsI Wiklund
Nov 1, 1995·Scandinavian Journal of Gastroenterology·E DimenäsI Wiklund

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Citations

Feb 4, 2014·Best Practice & Research. Clinical Gastroenterology·Marlies P SchijvenMark I van Berge Henegouwen
Feb 18, 2014·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Perttu NeuvonenTuomo Rantanen
Jan 13, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Donald E StullDavid W Sandor
Feb 13, 2001·BMJ : British Medical Journal·J DentN J Talley
Jul 12, 2005·BMC Gastroenterology·Samer El-DikaHolger J Schünemann
Jun 2, 2006·The New England Journal of Medicine·Brian C JacobsonCarlos A Camargo
Nov 22, 2007·BMC Gastroenterology·Siavosh Nasseri-MoghaddamReza Malekzadeh
Jan 22, 2008·World Journal of Gastroenterology : WJG·Xiangbing WangNeha Shah
Mar 20, 2008·World Journal of Gastroenterology : WJG·Wei LiZhong-Lin Yu
Mar 25, 2008·Therapeutics and Clinical Risk Management·Theo Scholten
Feb 28, 2009·World Journal of Gastroenterology : WJG·Ahmad MostaghniMehdi Saberi-Firoozi
Apr 8, 2011·World Journal of Gastroenterology : WJG·Takao TsuzukiKazuhide Yamamoto
Sep 25, 2012·World Journal of Gastroenterology : WJG·Fermín MearinJavier Zapardiel
Oct 11, 2012·World Journal of Gastroenterology : WJG·Shou-Wu LeeMing-Chih Chou
Jun 8, 2001·Surgical Endoscopy·C MöbiusJ R Siewert
Jan 27, 2009·Surgical Endoscopy·Ruxandra CiovicaMichael Gadenstätter
Nov 24, 2011·Diagnostic and Therapeutic Endoscopy·Luca DugheraMichele Chiaverina
Oct 22, 2005·Digestive Diseases and Sciences·Peter J KahrilasSheldon Sloan
Jan 11, 2007·Digestive Diseases and Sciences·Rosemary J YoungJohn K DiBaise
Aug 10, 2006·Digestive Diseases and Sciences·José Luis CallejaUNKNOWN SINERGE Study Group
Aug 20, 2009·Digestive Diseases and Sciences·Valesca Dall'AlbaSérgio Gabriel Silva de Barros
Jan 12, 2011·Digestive Diseases and Sciences·Ivan E Rascon-AguilarKenneth J Vega
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·Joshua J OfmanR Fass
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·M RobinsonUNKNOWN FAST Trial Investigators
Mar 29, 2000·Alimentary Pharmacology & Therapeutics·N D Yeomans, J Dent
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·N VakilK Bergenheim
Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Jukka Ronkainen, Lars Agréus
May 30, 2001·American Journal of Surgery·P G JacksonS R Evans
Jun 2, 2005·The Surgical Clinics of North America·Hiran C Fernando, Alberto de Hoyos
Feb 24, 2015·Journal of Diabetes·Paawan PunjabiSita Chokhavatia

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