The Impact of Gender and Estrogen on Striatal Dopaminergic Neurotoxicity

Annals of the New York Academy of Sciences
D B MillerS C Laws

Abstract

The reproductive properties of estrogen are well established, but it is now evident that this steroid hormone has substantial modulatory capabilities in nonreproductive systems. For example, estrogen may be neuroprotective as Alzheimer's disease progresses more slowly in women receiving hormone replacement therapy, and Parkinson's disease affects more men than women. Gender affects both the functional and biochemical responses of the nigral-striatal pathway to dopaminergically active compounds. To begin to evaluate the possible neuroprotective effects of estrogen in this pathway, we first determined if gender affected the dopaminergic striatal neurotoxicity induced by two different neurotoxicants, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and methamphetamine (METH). Both agents induced greater neurotoxicity in males than females as evidenced by greater striatal dopamine (DA) depletions. An examination of striatal levels of 1-methyl-4-phenylpyridium ion (MPP(+)) following MPTP treatment established that the observed gender differences were not due to metabolic/pharmacokinetic variables. The neurotoxicity of MPTP was then examined in ovariectomized (OVX) mice. Estrogen replacement reduced the DA, dihydroxyphenylacetic a...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R C GurD Berretta
Sep 1, 1986·British Journal of Industrial Medicine·E J Calabrese
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Nov 5, 1985·European Journal of Pharmacology·T Di PaoloP Bédard
Sep 15, 1973·The Journal of Comparative Neurology·D Pfaff, M Keiner
Oct 1, 1995·Environmental Health Perspectives·A M SotoF O Serrano
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Jul 5, 1996·Neuroscience Letters·C A SingerD M Dorsa
Sep 1, 1996·Neurotoxicology and Teratology·D E DluzenB Liu
Oct 1, 1996·Brain Pathology·R S ChanR M Sapolsky
May 1, 1997·Nature Medicine·J A Gustafsson

❮ Previous
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Citations

Jun 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Roberta FrigerioWalter A Rocca
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Bin Liu, Dean E Dluzen
May 20, 2016·Endocrine Reviews·Alessandro VillaAdriana Maggi
Mar 15, 2006·Expert Review of Neurotherapeutics·Lisa M Shulman, Viveca Bhat
Jul 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason R RichardsonGary W Miller
Apr 3, 2007·Nature Protocols·Vernice Jackson-Lewis, Serge Przedborski
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krishnan SriramJames P O'Callaghan
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rajappa S KenchappaVijayalakshmi Ravindranath
Sep 24, 2019·Endocrine Reviews·Elisabetta VegetoAngelo Poletti
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·M D BenedettiW A Rocca
Oct 22, 2002·Expert Opinion on Investigational Drugs·Bernd Moosmann, Christian Behl
Apr 5, 2003·Journal of Neurochemistry·Tiesong ShangCecilia J Hillard
Sep 10, 2005·Journal of Neurology·Yasuhiko BabaRyan J Uitti
Jan 17, 2008·Neuroimmunomodulation·Agnieszka CiesielskaAndrzej Członkowski
Feb 9, 2010·Journal of Neuroendocrinology·M L JohnsonC M Kuhn
Jul 1, 2005·Current Protocols in Pharmacology·Naomi P Visanji, Jonathan M Brotchie
Aug 12, 2000·Stress : the International Journal on the Biology of Stress·C A Frye, C M McCormick
Jun 5, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Demetrius M MaraganoreWalter A Rocca
Nov 15, 2001·Annals of Neurology·J Velísková, S L Moshé
Jul 6, 2010·Dermatologic Therapy·Rochelle R Torgerson
Mar 23, 2010·Toxicologic Pathology·Jeffrey A KramerAlan G E Wilson
Mar 6, 2012·Synapse·Luke S PothDean E Dluzen
May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Kelly Claire SimonAlberto Ascherio
Nov 16, 2004·Annals of the New York Academy of Sciences·Dean E Dluzen, Janet L McDermott
Jan 6, 2010·Environmental Health Perspectives·Nicole M GattoBeate Ritz
Apr 7, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Sun Ju ChungDemetrius M Maraganore
Sep 25, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Agnieszka CiesielskaA Członkowski
Jul 19, 2005·Annals of the New York Academy of Sciences·James A DykensNeil Howell
Apr 11, 2009·PloS One·Olga VareaFrancisco Wandosell
Apr 23, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie A MorenoRonald B Tjalkens

❮ Previous
Next ❯

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