PMID: 12788302Jun 6, 2003Paper

The impact of gender on the treatment and outcomes of patients with early reinfarction after fibrinolysis: insights from ASSENT-2

European Heart Journal
Michael C TjandrawidjajaASSENT-2 Investigators

Abstract

To assess gender differences in patients with early reinfarction after fibrinolysis for acute myocardial infarction (AMI) and the impact of these differences on treatment and outcomes. We studied 3.7% of men (n=481) and 4.8% of women (n=189) with early reinfarction after fibrinolysis for AMI in the ASSENT-2 trial of 16,949 patients. Women with reinfarction were older and more often had hypertension, diabetes, and major bleeding prior to reinfarction. Despite adjustment for these differences, women with reinfarction were less likely to receive repeat fibrinolytic therapy (OR: 0.55; 95% CI: 0.37-0.84). Aggressive treatment by either repeat fibrinolysis or urgent revascularization was associated with reduced 1-year mortality irrespective of gender. Death within 24 h of reinfarction was more frequent in women and accounted for a greater proportion of their 1-year mortality (56.0 vs 34.8%; p=0.02). The excess mortality in women at 1 year (27.3 vs 19.9%; p=0.045) was eliminated after adjustment for gender differences in baseline risk profile. Women with early reinfarction following fibrinolysis for AMI had more frequent early death and were managed less aggressively. These findings suggest the need for increased awareness and timely ...Continue Reading

Citations

May 8, 2004·Journal of Women's Health·Hava TabenkinJack H Medalie
Nov 26, 2008·Journal of cardiology·Masaharu IshiharaHiroki Ikenaga
Feb 16, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ole Steen MortensenUNKNOWN DANAMI-2 Study Group
Jan 27, 2016·Circulation·Laxmi S MehtaUNKNOWN American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Card

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