The impact of gender on urine C-peptide creatinine ratio interpretation.

Annals of Clinical Biochemistry
Nicholas J ThomasAndrew T Hattersley

Abstract

Urinary C-peptide creatinine ratio (UCPCR) is a non-invasive and convenient way of assessing endogenous insulin production. Adjusting for urine creatinine levels allows for differences in urine concentration. Creatinine excretion is known to be higher in men due to gender differences in muscle mass. We investigated the impact of gender on UCPCR. One hundred and seventy-six subjects underwent a mixed meal tolerance test (MMTT). We looked at the relationship between UCPCR on urine C-peptide and creatinine excretion rates using timed post-meal urine samples. A further 415 subjects had two-hour post-meal UCPCR measurements in order to derive gender-specific percentiles for different diabetes subgroups and controls. UCPCR was 1.48-fold higher in women (n=78) than men (n=98), median (interquartile range [IQR]): 1.88 (0.49-3.49) men versus 2.88 (1.58-4.91) nmol mmol(-1) women, P=0.01. This reflects a gender difference in creatinine excretion rates (11.5 [8.3-13.7] men versus 8.2 [5.6-9.1] women μmol min(-1) P<0.001). C-peptide excretion rate was similar in men and women (19.8 [5.2-37.0] versus 22.1 [7.4-40.5] pmol min(-1), P=0.7). UCPCR was higher in women in all subgroups defined by diabetes classification and treatment, except long-...Continue Reading

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Citations

Aug 1, 2015·Journal of Paediatrics and Child Health·Emma R SalisNatalie J Medlicott
Feb 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A G Jones, A T Hattersley
Nov 20, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·K Y ThongR E J Ryder
Jul 4, 2015·International Journal of Cancer. Journal International Du Cancer·Diederick DuijveszGuido Jenster
Aug 22, 2013·Annals of Clinical Biochemistry·Kyoko HiramatsuMasao Kawaikta
May 10, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Emma LeightonGregory C Jones
Jul 18, 2020·BMJ Open Diabetes Research & Care·Jamal M Salih, Darya S Abdulateef
Oct 18, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·D TatovicUNKNOWN MonoPepT1De Study Group
Sep 24, 2020·Animals : an Open Access Journal From MDPI·Sabrina FasoliGloria Isani

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Software Mentioned

UCPCR

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