PMID: 9557930Apr 29, 1998Paper

The impact of genetic hypertension on insulin secretion and glucoregulatory control in vivo: studies with the TGR(mRen2)27 transgenic rat

Journal of Hypertension
M J Holness, M C Sugden

Abstract

To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperinsulinaemia were examined in conscious, unrestrained TGR(mRen2)27 rats and age-matched transgene-negative controls. Glucose tolerance and insulin secretion were examined after intravenous administration of 500 mg glucose/kg body weight. Endogenous glucose production and whole-body glucose disposal were estimated using [3-3H]-glucose during euglycaemic-hyperinsulinaemic clamping. Muscle glucose utilization was estimated using 2-deoxy-[1-3H]-glucose. Despite there being higher insulin levels, whole-body glucose turnover was significantly lower in post-absorptive TGR(mRen2)27 rats than it was in transgene-negative controls. This was associated with significant suppression of glucose uptake/phosphorylation by oxidative skeletal muscles. TGR(mRen2)27 rats also exhibited significantly lower blood glucose levels, higher plasma insulin levels and higher rates of disappearance of glucose after intravenous administration of glucose. During hy...Continue Reading

References

Jul 1, 1978·Japanese Circulation Journal·Y YamoriY Komachi
Jul 1, 1978·Japanese Heart Journal·Y YamoriA Ooshima
Aug 19, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·Y V PostnovL P Solovyova
Jan 1, 1992·The American Journal of Physiology·L V Hryshko, D M Bers
Jun 1, 1990·Journal of Hypertension·P Ferrari, P Weidmann
May 1, 1990·Hypertension·D FinchK Kirchner
Feb 1, 1990·Metabolism: Clinical and Experimental·T PollareC Berne
Sep 15, 1988·Klinische Wochenschrift·W H HörlA Heidland
Apr 1, 1988·Metabolism: Clinical and Experimental·C E Mondon, G M Reaven
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·D C ShenG M Reaven
Mar 1, 1985·The Journal of Clinical Investigation·M ModanZ Fuchs
Dec 1, 1995·American Journal of Hypertension·M VéniantJ J Mullins
Jul 1, 1997·The American Journal of Physiology·T TamakiT Shiraishi

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Citations

May 9, 2012·Molecular and Cellular Endocrinology·Erik J Henriksen, Mujalin Prasannarong
Oct 23, 1998·Molecular and Cellular Endocrinology·M R Wilson, S J Hughes
Aug 2, 2013·Journal of the American Heart Association·Akinobu MaedaSatoshi Umemura
Jan 20, 2005·American Journal of Physiology. Endocrinology and Metabolism·Julie A SlonigerErik J Henriksen
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Melvin R HaydenJames R Sowers
Apr 13, 2007·American Journal of Physiology. Renal Physiology·Martin H de BorstHarry van Goor
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Brian Schreiber
Jul 23, 2002·Journal of Applied Physiology·Tyson R KinnickErik J Henriksen
Oct 21, 2004·American Journal of Physiology. Endocrinology and Metabolism·Mihaela C BlendeaJames R Sowers
Jan 8, 2015·American Journal of Physiology. Endocrinology and Metabolism·Guillaume A FavreEmmanuel Van Obberghen
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·James R Sowers
Jun 22, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erik J Henriksen

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