The impact of high-order epistasis in the within-host fitness of a positive-sense plant RNA virus

Journal of Evolutionary Biology
Jasna Lalić, Santiago F Elena


RNA viruses are the main source of emerging infectious diseases because of the evolutionary potential bestowed by their fast replication, large population sizes and high mutation and recombination rates. However, an equally important property, which is usually neglected, is the topography of the fitness landscape. How many fitness maxima exist and how well they are connected is especially interesting, as this determines the number of accessible evolutionary pathways. To address this question, we have reconstructed a region of the fitness landscape of tobacco etch potyvirus constituted by mutations observed during the experimental adaptation of the virus to the novel host Arabidopsis thaliana. Fitness was measured for many genotypes and showed the existence of multiple peaks and holes in the landscape. We found prevailing epistatic effects between mutations, with cases of reciprocal sign epistasis being common among pairs of mutations. We also found that high-order epistasis was as important as pairwise epistasis in their contribution to fitness. Therefore, results suggest that the landscape was rugged due to the existence of holes caused by lethal genotypes, that a very limited number of potential neutral paths exist and that i...Continue Reading


Sep 1, 1993·The Journal of Heredity·M LynchW Gabriel
Jul 20, 1999·Science·Holly A WichmanJ J Bull
May 1, 1964·Mutation Research·H J MULLER
Feb 25, 2005·The American Naturalist·Stephen R Proulx, Patrick C Phillips
Mar 24, 2005·Journal of Theoretical Biology·John J Welch, David Waxman
Sep 2, 2005·Journal of Evolutionary Biology·D Waxman, S Gavrilets
Sep 2, 2005·Journal of Evolutionary Biology·M Kirkpatrick, F Rousset
Oct 22, 2005·Science·Mark LunzerAntony M Dean
Dec 14, 2005·Trends in Plant Science·Christophe Robaglia, Carole Caranta
Apr 8, 2006·Science·Daniel M WeinreichDaniel L Hartl
May 17, 2006·Trends in Ecology & Evolution·Jerald B Johnson, Kristian S Omland
Jan 26, 2007·Nature·Frank J PoelwijkSander J Tans
Mar 6, 2007·Trends in Ecology & Evolution·Roger D KouyosSebastian Bonhoeffer
Aug 28, 2007·Genetics·Michael M DesaiMarcus W Feldman
Sep 28, 2007·Journal of Virology·Purificación CarrascoSantiago F Elena
Mar 21, 2008·Molecular Biology and Evolution·Susanna K RemoldPaul E Turner
Jun 12, 2008·PloS One·Patricia Agudelo-RomeroSantiago F Elena
Feb 24, 2009·Trends in Genetics : TIG·Ville Mustonen, Michael Lässig
May 22, 2009·The American Naturalist·J Arjan G M de VisserJoachim Krug
Jul 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elena R LozovskyDaniel L Hartl
Dec 23, 2009·Genetics·Hong GaoMarcus W Feldman
Feb 16, 2010·Virus Research·Leonor C Bedoya, José-Antonio Daròs
Mar 3, 2010·The Journal of Heredity·David W HallSara C Pope
May 19, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jasna LalićSantiago F Elena
Oct 13, 2010·Journal of Molecular Evolution·Andrea J Betancourt
Dec 21, 2010·Journal of Theoretical Biology·Frank J PoelwijkSander J Tans
Mar 29, 2011·Nature Genetics·Trevor HinkleySebastian Bonhoeffer
Apr 13, 2011·PloS One·Javier P MartínezAndreas Meyerhans
Jun 4, 2011·Science·Hsin-Hung ChouChristopher J Marx
Aug 31, 2011·PLoS Computational Biology·Jasper FrankeJoachim Krug
Oct 7, 2011·Proceedings. Biological Sciences·J Arjan G M de VisserSantiago F Elena
Feb 10, 2012·Molecular Biology and Evolution·Stéphanie BedhommeSantiago F Elena
Mar 14, 2012·PLoS Genetics·Roger D KouyosSebastian Bonhoeffer
Jul 20, 2012·Biology Letters·Jasna Lalić, Santiago F Elena
Oct 6, 2012·Journal of Theoretical Biology·Kristina CronaMiriam Barlow
Jul 31, 2013·Genome Biology·Andrea Velenich, Jeff Gore
Oct 25, 2013·Evolution; International Journal of Organic Evolution·Jeremy A Draghi, Joshua B Plotkin
Dec 3, 2013·Current Opinion in Genetics & Development·Daniel M WeinreichRobert B Heckendorn
Feb 6, 2014·Journal of Evolutionary Biology·J da Silva, S K Wyatt
May 24, 2014·PLoS Computational Biology·Devin Greene, Kristina Crona
Jun 4, 2014·Evolution; International Journal of Organic Evolution·Julia HillungSantiago F Elena
Jun 11, 2014·Nature Reviews. Genetics·J Arjan G M de Visser, Joachim Krug
Nov 21, 2014·BMC Systems Biology·Gabriel BosqueSantiago F Elena


Jul 20, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Santiago F Elena
Aug 19, 2016·Proceedings. Biological Sciences·Héctor CerveraSantiago F Elena
Jan 28, 2017·Evolution; International Journal of Organic Evolution·Peter C Zee, Gregory J Velicer
Sep 2, 2016·Journal of Virology·Héctor CerveraSantiago F Elena
Nov 23, 2018·Journal of Virology·Lele ZhaoSiobain Duffy
Aug 22, 2018·Heredity·J Arjan G M de VisserSebastian Matuszewski
Mar 29, 2019·Genome Biology and Evolution·Rubén GonzálezSantiago F Elena
Jul 27, 2018·Microbiology and Molecular Biology Reviews : MMBR·Bram Van den BerghJan Michiels
Mar 8, 2017·BMC Evolutionary Biology·Julia MinickaBeata Hasiów-Jaroszewska
Nov 20, 2020·Phytopathology·Michael J McLeishFernando García-Arenal

Related Concepts

Deviation, Epistatic
Plant Viruses
RNA Viruses
Epistasis, Genetic
Recombination, Genetic
Virus Replication
Arabidopsis thaliana <plant>

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

© 2021 Meta ULC. All rights reserved