The impact of high-salt exposure on cardiovascular development in the early chick embryo

The Journal of Experimental Biology
Guang WangXuesong Yang

Abstract

In this study, we show that high-salt exposure dramatically increases chick mortality during embryo development. As embryonic mortality at early stages mainly results from defects in cardiovascular development, we focused on heart formation and angiogenesis. We found that high-salt exposure enhanced the risk of abnormal heart tube looping and blood congestion in the heart chamber. In the presence of high salt, both ventricular cell proliferation and apoptosis increased. The high osmolarity induced by high salt in the ventricular cardiomyocytes resulted in incomplete differentiation, which might be due to reduced expression of Nkx2.5 and GATA4. Blood vessel density and diameter were suppressed by exposure to high salt in both the yolk sac membrane (YSM) and chorioallantoic membrane models. In addition, high-salt-induced suppression of angiogenesis occurred even at the vasculogenesis stage, as blood island formation was also inhibited by high-salt exposure. At the same time, cell proliferation was repressed and cell apoptosis was enhanced by high-salt exposure in YSM tissue. Moreover, the reduction in expression of HIF2 and FGF2 genes might cause high-salt-suppressed angiogenesis. Interestingly, we show that high-salt exposure ca...Continue Reading

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Citations

Feb 5, 2016·Journal of Agricultural and Food Chemistry·Guang WangXuesong Yang
Sep 9, 2017·Journal of Cellular Physiology·Jing ZhangXuesong Yang
Nov 1, 2018·Journal of Cellular Physiology·Shadia BeainiNassim Fares
May 20, 2019·Cell Stress & Chaperones·Xiaoyan LiangYanyan Zhao
Sep 18, 2021·Journal of Food Biochemistry·Zhijie BaoSongyi Lin

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