The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats

Frontiers in Behavioral Neuroscience
Dragica SelakovicGvozden Rosic

Abstract

The aim of this study was to evaluate alterations in depressive-like behaviors in rats following chronic administration of a supraphysiological dose of anabolic androgenic steroids (AASs) as well as exposure to a prolonged exercise protocol. The role of hippocampal sex hormones receptors in the modulation of depressive-like behavior was also assessed. A total of 48 male Wistar albino rats were divided into six groups: control, exercise (1 h/day, five consecutive days), nandrolone-decanoate (ND, 20 mg/kg/week, in a single dose), exercise plus ND, testosterone-enanthate (TE, 20 mg/kg/week, in a single dose), and exercise plus TE. After the 6-week protocols were complete, the rats underwent behavioral testing in the tail suspension test (TST). Rats were sacrificed for the collection of blood samples, to determine sex hormones levels, and isolation of the hippocampus, to determine [androgen receptors (AR) and estrogen receptors α (ERα)] expression. ND and TE treatment induced significant depressive-like behavior, opposing the antidepressant effect of exercise. Chronic TE administration elevated testosterone (T) and dihydrotestosterone (DHT) serum levels, and this was augmented by exercise. In contrast, ND and exercise alone did not...Continue Reading

References

Apr 1, 1988·The American Journal of Psychiatry·H G Pope, D L Katz
Aug 1, 1996·Medicine and Science in Sports and Exercise·G A WittertR A Donald
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·I Jung-Testas, E E Baulieu
Oct 31, 1998·Brain Research. Molecular Brain Research·H S OliffC W Cotman
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Dec 22, 1999·Psychotherapy and Psychosomatics·A J Gruber, H G Pope
Dec 28, 1999·Public Health Nutrition·K R Fox
Oct 18, 2002·The European Journal of Neuroscience·Raffaella MolteniFernando Gómez-Pinilla
Jul 2, 2003·The Journal of Comparative Neurology·Laura A TowartTeresa A Milner
Jul 31, 2003·Molecular Psychiatry·P BrambillaJ C Soares
Sep 25, 2003·Neuroscience and Biobehavioral Reviews·Ann S Clark, Leslie P Henderson
Dec 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yasushi HojoSuguru Kawato
Sep 8, 2004·Endocrine Journal·Masato TakahashiToshihiko Kohno
Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Graziano PinnaAlessandro Guidotti
Mar 17, 2005·The International Journal of Neuropsychopharmacology·Astrid BjørnebekkStefan Brené
Nov 18, 2005·Behavioural Brain Research·Hang ZhengF Halberg
Dec 17, 2005·International Journal of Cardiology·Mario Mateus SugizakiAntonio Carlos Cicogna
Jan 28, 2006·Preventive Medicine·M H M De MoorE J C De Geus
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
Apr 13, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ricardo Vinícius Ledesma ContartezeMaria Alice Rostom De Mello
Feb 13, 2008·Brain Research·Catharine H DumanRonald S Duman
May 14, 2008·Neurochemical Research·Graziano PinnaErminio Costa
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Jan 27, 2009·Brain & Development·Sérgio Gomes da SilvaRicardo Mario Arida
Apr 30, 2009·Seminars in Reproductive Medicine·Charles E RoselliPatricia D Hurn
Oct 14, 2009·Pharmacology, Biochemistry, and Behavior·Anachristina E MinerlyVanya Quinones-Jenab
Jan 26, 2010·Physiology & Behavior·Augustus R Lumia, Marilyn Y McGinnis
Feb 16, 2010·Regulatory Toxicology and Pharmacology : RTP·Jan van AmsterdamFred Hartgens
Nov 16, 2010·Irish Journal of Medical Science·P C DinasA D Flouris
Nov 17, 2010·Molecular Psychiatry·B LuscherN Sahir
Mar 15, 2012·Neuroendocrinology·Rebecca L CunninghamMarilyn Y McGinnis

❮ Previous
Next ❯

Citations

Dec 22, 2019·Biomolecules·Rade VukovicGvozden Rosic
Jul 17, 2020·CNS & Neurological Disorders Drug Targets·Alice Barros Câmara, Igor Augusto Brandão
Jul 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ze ChangRong-Juan Guo

❮ Previous
Next ❯

Methods Mentioned

BETA
genetic modification
ELISA
total hippocampal section
total

Software Mentioned

SPSS
SPSS Statistics
ARRIVE
AxioVision

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.