The impact of histopathologic diagnosis on the proper management of testis neoplasms

Nature Clinical Practice. Oncology
Giovanni PontiEmanuele Zucca

Abstract

A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits. Brain MRI and CT-guided biopsy. Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system. High-dose methotrexate alone or in combination with high-dose cytarabine.

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Citations

Nov 28, 2013·Blood·Chan Y CheahJohn F Seymour

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