The impact of human immunodeficiency virus infection on obstetric hemorrhage and blood transfusion in South Africa

Transfusion
Evan M BlochInternational Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

Abstract

Globally, as in South Africa, obstetric hemorrhage (OH) remains a leading cause of maternal mortality and morbidity. Although blood transfusion is critical to OH management, the incidence and predictors of transfusion as well as their relation to human immunodeficiency virus (HIV) infection are poorly described. A cross-sectional study was conducted of all peripartum patients at four major hospitals in South Africa (April to July 2012). Comprehensive clinical data were collected on patients who sustained OH and/or were transfused. Logistic regression was used to model risk factors for OH and transfusion. A total of 15,725 peripartum women were evaluated, of whom 3969 (25.2%) were HIV positive. Overall, 387 (2.5%) women sustained OH and 438 (2.8%) received transfusions, including 213 (1.4%) women with both OH and transfusion. There was no significant difference in OH incidence between HIV-positive (2.8%) and HIV-negative (2.3%) patients (adjusted odds ratio [OR], 0.95; 95% confidence interval [CI], 0.72-1.25). In contrast, the incidence of blood transfusion was significantly higher in HIV-positive (3.7%) than in HIV-negative (2.4%) patients (adjusted OR, 1.52; 95% CI, 1.14-2.03). Other risk factors for transfusion included OH, l...Continue Reading

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Citations

Apr 5, 2016·Hematology/oncology Clinics of North America·David J RobertsImelda Bates
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Jul 11, 2018·Transfusion·Evan M BlochUNKNOWN South Africa Program of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)
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Feb 16, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·J C HullUNKNOWN REDS-III South Africa Program

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