The Impact of Hypoparathyroidism Treatment on the Kidney in Children: Long-Term Retrospective Follow-Up Study

The Journal of Clinical Endocrinology and Metabolism
Isaac LevyJennifer Harrington

Abstract

Adults with hypoparathyroidism have significant rates of nephrocalcinosis and impaired renal function. Little is known about the impact of hypoparathyroidism treatment on renal function in children. To determine the prevalence and predictors for renal abnormalities (nephrocalcinosis and decreased estimated glomerular filtration rate [eGFR]) in children with treated hypoparathyroidism. A retrospective chart review of patients with permanent hypoparathyroidism at the Hospital for Sick Children, Toronto, between 1996 and 2013. Data of 29 patients (15 males) followed for at least 1 year with documented hypoparathyroidism were analyzed. Mean duration of follow up was 7.4 ± 5 years. The presence or absence of nephrocalcinosis as detected on ultrasound and eGFR were evaluated. Time-weighted average serum measurements were calculated for all biochemical variables. Mean total and ionized serum calcium were 8.9 ± 0.8 and 4.6 ± 0.5 mg/dL, respectively. Nephrocalcinosis was observed in 38% of the subjects, with the most significant predictors being the degree of relative hypercalcemia and hyperphosphatemia (R(2) = 0.47, P < .01). Although all patients had an eGFR greater than 60, in 45% of the children, the eGRF was between 60 and 90 mL/mi...Continue Reading

Citations

Dec 3, 2016·Archives of Endocrinology and Metabolism·Maicon Piana LopesCarolina A Moreira
Sep 1, 2017·Nature Reviews. Disease Primers·Michael MannstadtDolores M Shoback
Jan 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Soma SahaRavinder Goswami
Jul 8, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Omar BjanidMaria Szczepańska
Apr 26, 2018·Archives of Endocrinology and Metabolism·Sergio Setsuo MaedaMarise Lazaretti-Castro
Feb 1, 2017·Frontiers in Endocrinology·Ejigayehu G Abate, Bart L Clarke
May 3, 2019·The New England Journal of Medicine·Rachel I Gafni, Michael T Collins
Dec 15, 2020·Annales d'endocrinologie·Mélodie MoscaJustine Bacchetta
Mar 3, 2021·American Journal of Surgery·Ruth ObiarinzeHerbert Chen
Jun 24, 2020·Seminars in Pediatric Surgery·Michael J Zobel, Benjamin E Padilla
Sep 8, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pediredla KarunakarAakash Chandran Chidambaram

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