The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis

Cytokine
Inês MesquitaRicardo Silvestre

Abstract

Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of L. donovani infection by analyzing the parasite burden in the spleen and liver of the infected pMT-10 and WT mice as well as the histopathological alterations upon IL-10 induction. Furthermore, the profile of cytokines expressed by T cells was assessed. Our results demonstrate that an increase in IL-10 production has an impact early but not later after infection. This specific temporal role for IL-10-mediated susceptibility to VL is of interest.

Citations

Sep 10, 2020·The American Journal of Tropical Medicine and Hygiene·Samuel R AquinoRodrigo F Carmo
Jan 16, 2021·Biochemical Society Transactions·Thalia Pacheco-FernandezAbhay R Satoskar
Nov 1, 2020·Cytokine·Renuka BhorKalpana Pai
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Mukesh SamantPrashant Khare
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Thalia Pacheco-FernandezHira L Nakhasi
Feb 20, 2021·Cytokine: X·Sonia AndréJérôme Estaquier

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