PMID: 15388995Sep 25, 2004Paper

The impact of inaccurate reporting of condom use and imperfect diagnosis of sexually transmitted disease infection in studies of condom effectiveness: a simulation-based assessment

Sexually Transmitted Diseases
Owen J Devine, Sevgi O Aral

Abstract

The effectiveness of condoms in reducing sexually transmitted disease (STD) infection risk has been debated in the face of equivocal epidemiologic evidence. We assessed the potential magnitude of bias in condom effectiveness studies resulting from inaccurate reporting of condom use behavior and misdiagnosis of STD infection status. The goal of this study was to illustrate the magnitude of bias in condom effectiveness studies in the presence of inaccurate condom use reporting and diagnostic misclassification. We used probabilistic simulations to mimic plausible outcomes for hypothetical prospective and retrospective condom effectiveness studies subject to both inaccurate reporting of the participants' true condom use and diagnostic error. The simulations were conducted by generating a series of binomial (yes, no) random variables corresponding with STD infection status and accurate diagnosis of infection. The simulation results illustrate that failure to address reporting and diagnostic errors can lead to a substantial bias in studies of condom effectiveness. This bias resulted in a roughly 25% to 30% reduction in the probability of detecting a true 2-fold reduction of infection risk resulting from using condoms. Inaccurate repo...Continue Reading

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Mar 26, 2003·Statistics in Medicine·Tor D TostesonMargaret Karagas

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Citations

Mar 8, 2012·The Journal of Infectious Diseases·Kimberly K ReppUNKNOWN HIM study
Mar 8, 2011·Obstetrical & Gynecological Survey·Christie M J L CookseyJennifer Lee
Mar 31, 2006·Studies in Family Planning·Mary L PlummerDavid A Ross
Jul 26, 2005·Sexually Transmitted Diseases·Richard CrosbyMichelle Staples-Horne
Oct 13, 2007·Sexual Health·Richard CrosbyAdewale Troutman

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