The impact of increased body mass index on the clinical course of Crohn's disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
David J HassGary R Lichtenstein

Abstract

Tumor necrosis factor-alpha production in adipose tissue is well documented. Crohn's disease (CD) patients with increased adipose tissue may have more severe disease. This study evaluated overweight patients with CD to determine if their clinical course differs from those with a normal or low body mass index (BMI). Patients at the Hospital of the University of Pennsylvania from 1997 to 2002 were included. Data were collected from outpatient records and standardized interviews. Overweight was defined as a BMI of 25 kg/m2 or higher. The primary outcome was time to first surgery. Secondary outcomes included age at diagnosis, number of surgeries, and escalation of therapy. Patients with a BMI of 25 kg/m2 or higher at diagnosis were compared with patients with a BMI of less than 25 kg/m2 using statistical analyses. Survival analysis compared time to first surgery. A total of 148 patients were included. Forty-eight (32.4%) had a BMI of 25 kg/m2 or higher at diagnosis. Patients with a BMI of 25 kg/m2 or higher were older at diagnosis; 35 years vs 22.5 years for patients with a BMI of less than 25 kg/m2 (P = .0001). The number of surgeries, escalation of therapy, and disease distribution did not differ between the 2 groups. A significa...Continue Reading

Citations

Mar 13, 2012·Inflammatory Bowel Diseases·Christopher FinkCharalabos Pothoulakis
Apr 11, 2012·Inflammatory Bowel Diseases·Caroline HwangUma Mahadevan
Mar 3, 2012·Forensic Science, Medicine, and Pathology·Roger W Byard
Dec 14, 2011·Immunologic Research·Kitty P CheungJulie M Jameson
Jun 3, 2010·World Journal of Gastroenterology : WJG·Edouard LouisCatherine Reenaers
Aug 10, 2012·World Journal of Gastroenterology : WJG·Eduard Cabré, Eugeni Domènech
Nov 9, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Elif YorulmazIlyas Tuncer
Aug 13, 2015·International Journal of Molecular Sciences·Fernando Zapata-GonzalezCristóbal Richart
Apr 30, 2015·Biogerontology·Daniela Frasca, Bonnie B Blomberg
Oct 30, 2015·Digestive Diseases and Sciences·Sudeep Dhoj ThapaNirmal Kaur
Oct 1, 2015·Obesity Surgery·Ali AminianStacy A Brethauer
May 15, 2015·Journal of Crohn's & Colitis·Shi Sum PoonSreedhar Subramanian
Mar 21, 2016·Journal of Crohn's & Colitis·Peter BrownVenkataraman Subramanian
Mar 25, 2015·Digestive Diseases and Sciences·Avegail FloresLinda A Feagins
Dec 31, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Andrei KeidarNir Wasserberg
Oct 14, 2014·Frontiers in Immunology·Lea I Kredel, Britta Siegmund
Nov 14, 2014·International Journal of Colorectal Disease·Denia Stabroth-AkilWolfgang Kruis
Dec 4, 2014·PloS One·Julie M DaviesMaria T Abreu
Aug 18, 2016·Frontiers in Immunology·Abigail BassonFabio Cominelli
Jun 12, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·André Van GossumUNKNOWN ESPEN
Feb 16, 2017·Arquivos De Gastroenterologia·Ivi Ribeiro BackLigia Yukie Sassaki
Jan 8, 2015·Inflammatory Bowel Diseases·Hamed KhaliliAndrew T Chan
Oct 25, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Abigail Basson
Mar 6, 2018·Inflammatory Bowel Diseases·Xian Hua GaoBo Shen
Feb 28, 2015·Inflammatory Bowel Diseases·Patricia D JonesMillie D Long
Jul 17, 2015·Inflammatory Bowel Diseases·Patricia L PringleHamed Khalili
Jul 12, 2017·Inflammatory Bowel Diseases·Manish B SinglaJohn Betteridge
Sep 19, 2017·Inflammatory Bowel Diseases·Nicholas P McKennaAmy L Lightner
Aug 5, 2015·Inflammatory Bowel Diseases·Jennifer L SeminerioDavid G Binion
Jan 20, 2018·Journal of Clinical Pharmacology·Janelle D VaughnsGilbert J Burckart
Jan 23, 2018·Current Opinion in Gastroenterology·Sophia M SwansonTimothy L Zisman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Inflammatory Bowel Diseases
Millie D LongImproveCareNow Collaborative for Pediatric IBD
European Journal of Immunology
Shawn WinerH-Michael Dosch
© 2022 Meta ULC. All rights reserved