The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer

Anticancer Research
Masaaki NishiMitsuo Shimada

Abstract

Indoleamine 2,3-dioxygenase (IDO) down-regulates T cell activation, attenuates regulatory T cell (Treg) activation and is related to immune tolerance. The aim of the study was to clarify the significance of IDO expression and analyze the relationships between the expression of IDO, TGF-β, and Foxp3 in gastric cancer (GC). A total of 60 patients who underwent curative gastrectomy for stage III gastric cancer were included in the study. The expression of IDO, TGF-β, and Foxp3 was examined by immunohistochemistry and the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. IDO expression was not positively correlated with any of the factors examined. IDO expression was positively correlated with TGF-β expression (p<0.05), and TGF-β expression was positively correlated with FoxP3 expression (p<0.05). Overall survival (OS) rates were significantly poorer in the IDO-positive group compared to the IDO-negative group (3-year OS, 78.5% vs. 90%, respectively; p<0.05). Multivariate analysis confirmed IDO expression as independent prognostic factors in OS. Disease-free survival (DFS) was significantly poorer in the IDO-positive group compared to the IDO-negative group ...Continue Reading

Citations

Mar 15, 2020·Journal of Leukocyte Biology·Maria Grazia RefoloRosalba D'Alessandro
Apr 24, 2020·British Journal of Clinical Pharmacology·Yara AbdouMarc S Ernstoff
Dec 24, 2018·Therapeutic Advances in Gastroenterology·Aleksandar AcovicVladislav Volarevic
Apr 30, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Shaolei LuMurray B Resnick
Jul 14, 2020·Seminars in Cancer Biology·Ombretta MelaiuFederica Gemignani
Feb 3, 2021·European Journal of Pharmacology·Moein Ala
Nov 12, 2021·The Journal of Medical Investigation : JMI·Masaaki NishiToshiaki Yoshimoto
Nov 18, 2021·Immunotherapy·Christo KoleDimitrios Schizas
Nov 20, 2021·PloS One·Chie TakasuMitsuo Shimada

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