The impact of inspiratory pressure on stroke volume variation and the evaluation of indexing stroke volume variation to inspiratory pressure under various preload conditions in experimental animals

Journal of Anesthesia
Yu KawazoeSeiya Kato

Abstract

Stroke volume variation (SVV) measures fluid responsiveness, enabling optimal fluid management under positive pressure ventilation. We aimed to investigate the effect of peak inspiratory pressure (PIP) on SVV under various preload conditions in experimental animals and to ascertain whether SVV indexed to PIP decreases the effect. Mild and moderate hemorrhage models were created in nine anesthetized, mechanically ventilated beagle dogs by sequentially removing 10 and then an additional 10 ml/kg of blood, respectively. In all the animals, PIP was incrementally increased by 4 cmH2O, from 5 to 21 cmH2O. SVV was measured by arterial pulse contour analysis. Stroke volume was derived using a thermodilution method, and central venous pressure and mean arterial pressure were also measured. SVV increased according to PIP with significant correlation at baseline, with mild hemorrhage and moderate hemorrhage. PIP regression coefficients at baseline and in the mild and moderate hemorrhage models were 0.59, 0.86, and 1.4, respectively. Two-way repeated-measures analysis of variance showed that PIP and the degree of hemorrhage had a significant interaction effect on SVV (p = 0.0016). SVV indexed to PIP reflected the hemorrhage status regardle...Continue Reading

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Citations

Apr 3, 2016·Best Practice & Research. Clinical Anaesthesiology·W Kirke Rogers, Michael Todd
Jul 31, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Mohamed AlaaAndré P Lourenço
Apr 5, 2018·Frontiers in Veterinary Science·Jessica Noel-Morgan, William W Muir
Oct 18, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Mahmoud AbdellatifAndré P Lourenço
Jan 28, 2020·Clinical and Experimental Pharmacology & Physiology·Tsuyoshi NakashimaSeiya Kato

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