The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran

Nutrients
Ladan MehranFereidoun Azizi

Abstract

Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa. In the current national study, among 1,382,229 live births delivered between March 2010 and March 2011, 1,288,237 neonates were screened for detecting CH by TSH (thyroid stimulating hormone) measurement via heel prick sampling. Simultaneously, a total of 11,280 school-aged children, aged 7-8 years, were selected using random multi-cluster sampling for measurement of urinary iodine. A negative correlation was found between median urinary iodine (MUI) and the recall rate (r = -0.33, p = 0.03). No correlation was found between MUIC (median urinary iodine concentration) and the incidence rate of CH. Linear regression analysis showed a 0.1% increase in the recall rate for a one unit decrease in MUIC (β = -0.11, 95% CI: -0.2, -0.1, p = 0.03). MUIC, at a cut-off point of 144.7 µg/L, was predictive for a recall rate < 3% (p = 0.05). Frequencies of TSH ≥ 5 mU/L may be a more sensitive indicator for iodine status during pregnancy rather than in the general population. As hi...Continue Reading

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Citations

Mar 16, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ladan MehranFereidoun Azizi
Sep 28, 2018·Food Science & Nutrition·Hani Choudhry, Md Nasrullah
Jan 15, 2019·Indian Journal of Pediatrics·P S N Menon
Jul 4, 2019·The American Journal of Clinical Nutrition·Molla Mesele WassieShao Jia Zhou
Apr 6, 2021·International Journal of Endocrinology and Metabolism·Shahin YarahmadiKhaled Rahmani

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