PMID: 11604341Oct 18, 2001Paper

The impact of ischaemic preconditioning on spinal cord blood flow and paraplegia

Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
T UenoT Itoh

Abstract

We investigated the effect of ischaemic preconditioning (IP) on ischaemic spinal cord injury in a rabbit model. Fourteen rabbits were divided into IP and control groups of seven rabbits each. We repeated 3-min clamping of the infrarenal abdominal aorta and 3-min reperfusion twice (preconditioning), followed by 15 min clamping in the IP group. In the control group, the aorta was clamped for 15 min without preconditioning. Lumbar cord blood flow and systemic blood pressure were measured until 3 h of reperfusion. Another 14 rabbits underwent the same procedures with or without IP and neurologic status was assessed on the second postoperative day. The percent change in lumbar cord blood flow after reperfusion was significantly greater (P=0.013) in the IP group despite lower mean blood pressure. There was no significant difference in overall neurologic status (P=0.461) but the incidence of spastic paraplegia in the IP group was lower (14%, 1/7) than that of control group (43%, 3/7). IP increased postischaemic lumbar cord blood flow and contributed to lower incidence of spastic paraplegia.

References

Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·T P JacobsG Feuerstein
Apr 1, 1990·Circulation Research·R J SchottW Schaper
May 1, 1997·The Annals of Thoracic Surgery·K MatsuyamaR Muraoka
Mar 1, 1997·Journal of Molecular and Cellular Cardiology·E K IliodromitisD J Hearse
Oct 6, 1999·The Annals of Thoracic Surgery·D A ZvaraJ C Lundell

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Citations

Jan 2, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Han HuangJin Liu
Sep 6, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Ioannis K Toumpoulis, Constantine E Anagnostopoulos
Jan 8, 2004·Seminars in Thoracic and Cardiovascular Surgery·T Brett ReeceDavid C Cassada
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Ioannis K ToumpoulisDemosthenes G Katritsis
Oct 5, 2006·Current Opinion in Anaesthesiology·Peter Rock, Zhenhai Yao

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