The impact of joint bleeding and synovitis on physical ability and joint function in a murine model of haemophilic synovitis

Haemophilia : the Official Journal of the World Federation of Hemophilia
C Mejia-CarvajalLeonard A Valentino

Abstract

Haemophilia is a congenital disorder that commonly results in musculoskeletal bleeding and orthopaedic complications. After an acute joint haemorrhage, an increase in intra-articular pressure and inflammation cause pain, swelling and limited motion. Blood in the joint space provokes a proliferative disorder known as haemophilic synovitis. Overgrowth of the synovial membrane causes mechanical dysfunction. Eventually, there is destruction of the articular surface and underlying bone. The aim of this project was to test the hypothesis that a minimum number of haemarthroses negatively impacts on joint function and that this would be reflected by decreased physical performance of experimental animals. Mice deficient in factor VIII coagulant activity were trained to ambulate on a rotating rod then injured three times at weekly intervals. Their ability to walk was then compared to a group of uninjured mice. Cohorts of mice were killed after 1, 2 or 3 months and the knee joints examined by gross and histological methods. The results supported the following conclusions: (i) haemophilic mice can be trained to ambulate on a rotating rod; (ii) acute hemarthrosis temporarily impairs their ability to ambulate and (iii) following recovery fro...Continue Reading

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Citations

Nov 30, 2013·Arthritis Research & Therapy·Michael Karl BoettgerThomas Hilberg
Dec 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·P E Monahan
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·G RoosendaalF P J G Lafeber
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanV Jimenez-Yuste
Mar 27, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Astrid E PullesFloris P J G Lafeber
May 28, 2021·Expert Review of Hematology·E Carlos Rodriguez-Merchan, Hortensia De la Corte-Rodriguez
Jul 2, 2021·Journal of Thrombosis and Haemostasis : JTH·Roberta GualtierottiFlora Peyvandi

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