The impact of l-dopa on attentional impairments in a rat model of Parkinson's disease

Elizabeth S SmithHongjoo J Lee


Attentional deficits including difficulty in switching attention between tasks or rules, sustaining attention, and selectively attending to specific stimuli are commonly seen in patients with Parkinson's disease (PD). While these deficits are frequently reported, it is unclear how traditional dopamine replacement therapy such as l-dopa affects these deficits. In a rat model of PD in which dopamine is unilaterally depleted with a 6-hydroxydopamine infusion to the medial forebrain bundle, we first examined the impact of acute and chronic l-dopa treatment on attention switching as modeled by disengagement behavior (i.e. the ability to disengage from an on-going behavior such as eating or drinking to attend to perioral stimulation). Then, in a separate experiment, we evaluated the effects of l-dopa treatment on selective and sustained attention deficits using a five choice task. Our data suggest that the l-dopa dose necessary to recover motor function can successfully restore attention switching behavior (i.e. disengagement behavior), but further worsens performance in the selective and sustained attention task. Furthermore, this same dose was responsible for inducing dyskinesias in rats given chronic daily injections. Taken togeth...Continue Reading


Dec 1, 1990·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·M H Sharpe
Apr 24, 2002·Journal of Cognitive Neuroscience·Susan M Ravizza, Michael A Ciranni
Nov 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frank P BymasterKenneth W Perry
Nov 20, 2003·Neuroscience and Biobehavioral Reviews·J M Swanson, N D Volkow
Sep 3, 2004·The European Journal of Neuroscience·E Decamp, J S Schneider
Feb 6, 2007·Nature Neuroscience·Susheel VijayraghavanAmy F T Arnsten
Mar 23, 2007·Annual Review of Neuroscience·Howard L FieldsSaleem M Nicola
Jul 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emma S J RobinsonTrevor W Robbins
Aug 9, 2008·Neuropsychologia·Ahmed A MoustafaMichael J Frank
Sep 22, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Nao J GamoAmy F T Arnsten
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Antoine R AdamantidisLuis de Lecea
Jan 11, 2012·Neuroscience Letters·Shanshan ZhouKai Wang
Dec 1, 2012·Parkinsonism & Related Disorders·Kathy DujardinLuc Defebvre
Dec 15, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Jay S SchneiderErwan Bezard
Jan 16, 2013·Behavioral Neuroscience·Elizabeth S SmithHongjoo J Lee
Mar 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel WeintraubUNKNOWN Parkinson's Progression Markers Initiative

❮ Previous
Next ❯


Apr 12, 2019·Biomolecules·Fabio Del BelloWilma Quaglia
Jul 3, 2021·Biomedicines·Mélina DecourtPierre-Olivier Fernagut

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.