The Impact of Lactobacillus Probiotics on the Gut Microbiota in Children With Short Bowel Syndrome

The Journal of Surgical Research
Hannah G PiperAndrew Y Koh

Abstract

Children with short bowel syndrome (SBS) frequently struggle with malabsorption and poor growth. The intestinal microbiota plays an important role in gut function, and children with SBS have known deficiencies in some commensal gut microbes. One strategy to enhance the gut microbiota is by taking probiotics. However, the efficacy of this approach is not well established. We hypothesized that probiotic supplementation would result in increased levels of the supplemented bacteria and improved growth. Children with SBS who had weaned from parenteral nutrition but with suboptimal growth were randomized to receive probiotics (Lactobacillus rhamnosus and Lactobacillus johnsonii) or placebo daily for 2 mo. The gut microbiota from monthly stool samples were compared between groups using 16S ribosomal ribonucleic acid sequencing and quantitative polymerase chain reaction. Growth between groups was also compared. Statistical analysis was completed using Mann-Whitney, Kruskal-Wallis, and chi-square tests as appropriate. Eighteen children with SBS completed the study (n = 9 per group). There were no significant changes to the major bacterial families in either group. Median relative abundance of Lactobacillus did not differ between groups ...Continue Reading

Citations

Aug 21, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Nandini ChannabasappaHannah Piper
Aug 2, 2021·Seminars in Perinatology·Rohit Josyabhatla, Essam M Imseis
May 14, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Esther G NeelisKonstantinos Gerasimidis
Oct 31, 2021·Archives of Disease in Childhood·Konstantinos GerasimidisVaios Svolos

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