The impact of lipid oxidation on the functioning of a lung surfactant model

Physical Chemistry Chemical Physics : PCCP
Anna Stachowicz-KuśnierzBeata Korchowiec

Abstract

Apart from being responsible for sufficient pulmonary compliance and preventing alveolar collapse, lung surfactant (LS) also forms the first barrier for uptake of inhaled pathogens. As such it is susceptible to damage caused by various deleterious compounds present in air, e.g. oxidants capable of oxidizing unsaturated LS lipids. This study examines the consequences of oxidizing 20% of unsaturated lipids in an LS model: a mixed 1 : 1 DPPC : POPC monolayer. POxnoPC (1-palmitoyl-2-(9-oxo-nonanoyl)-sn-glycero-3-phosphocholine) is considered as the main oxidation product. Experimental surface pressure-area isotherms and polarization-modulation infrared reflection-absorption spectroscopy are employed to probe changes in the macroscopic properties of the unsaturated lipid monolayer induced by oxidation. Microscopic details of the influence of oxidation on the monolayer's phase behavior are elucidated by molecular dynamics simulations at varying lipid packing. We demonstrate that unsaturated lipid oxidation shifts the isotherm towards larger areas and advances monolayer collapse. This is caused by a reversal of the oxidized sn-2 chains of POxnoPC towards the subphase, driven by electrostatic interactions between the aldehyde, glycerin...Continue Reading

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S SchürchJ A Clements
Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
Nov 14, 1998·Biochimica Et Biophysica Acta·J Goerke
Nov 14, 1998·Biochimica Et Biophysica Acta·R VeldhuizenF Possmayer
Feb 22, 2001·Annual Review of Physiology·E Crouch, J R Wright
Mar 22, 2001·Biophysical Journal·J M Crane, S B Hall
Aug 7, 2002·Current Opinion in Structural Biology·Barbora PiknovaStephen B Hall
Oct 29, 2002·Lancet·Bert Brunekreef, Stephen T Holgate
Sep 30, 2004·Biophysical Journal·Coralie AlonsoJoseph A Zasadzinski
Oct 8, 2005·Journal of Computational Chemistry·David Van Der SpoelHerman J C Berendsen
Feb 7, 2006·Journal of Molecular Graphics & Modelling·Junmei WangDavid A Case
Apr 4, 2006·Biophysical Journal·Karen SabatiniPaavo K J Kinnunen
Apr 8, 2006·Chemistry and Physics of Lipids·Alicia G Serrano, Jesús Pérez-Gil
Apr 28, 2007·The Journal of Chemical Physics·C Vega, E de Miguel
Nov 2, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Svetlana BaoukinaD Peter Tieleman
Nov 17, 2007·Paediatric Respiratory Reviews·Sundeep Salvi
Dec 18, 2007·Journal of Toxicology and Environmental Health. Part a·Michal Krzyzanowski
Jan 18, 2008·Biophysical Journal·Susan L Duncan, Ronald G Larson
Apr 25, 2008·Biochimica Et Biophysica Acta·Yi Y ZuoFred Possmayer
Apr 15, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Lenka BeranovaPavel Jungwirth
May 4, 2010·Respiratory Physiology & Neurobiology·Sandra OrgeigFred Possmayer
Oct 5, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Katherine C ThompsonArwel V Hughes
Jun 10, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Hong ZhangYi Y Zuo
Jun 21, 2011·The Journal of Physical Chemistry. B·Katarzyna CzaplaEwa Rogalska
Dec 31, 2011·Biochimica Et Biophysica Acta·Eleonora KeatingRuud A W Veldhuizen
Jan 5, 2012·BMC Research Notes·Andreas MenkeDivya Mehta
Jan 10, 2012·Biophysical Journal·Prajnaparamita DharJoseph A Zasadzinski
Feb 23, 2012·The Journal of Physical Chemistry. B·Joakim P M Jämbeck, Alexander P Lyubartsev
Oct 31, 2012·Colloids and Surfaces. B, Biointerfaces·Jenifer Rubio-MagnietoEwa Rogalska
Mar 14, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Katherine C ThompsonArwel V Hughes
Jan 9, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Lucie HuynhNadège Jamin

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Citations

Feb 8, 2019·Environmental Science. Processes & Impacts·Beata KorchowiecJacek Korchowiec
Aug 5, 2021·Current Research in Toxicology·Emilie Da SilvaJorid B Sørli
Mar 20, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Fujia TianNing Gu
Jan 7, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Agnieszka OlżyńskaLukasz Cwiklik
Dec 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Nadia Milad, Mathieu C Morissette

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