The impact of luteal phase support on endometrial estrogen and progesterone receptor expression: a randomized control trial.

Reproductive Biology and Endocrinology : RB&E
Paul R BrezinaYulian Zhao

Abstract

To assess the impact of luteal phase support on the expression of estrogen receptor (ER) alpha and progesterone receptors B (PR-B) on the endometrium of oocyte donors undergoing controlled ovarian hyperstimulation (COH). A prospective, randomized study was conducted in women undergoing controlled ovarian hyperstimulation for oocyte donation. Participants were randomized to receive no luteal support, vaginal progesterone alone, or vaginal progesterone plus orally administered 17 Beta estradiol. Endometrial biopsies were obtained at 4 time points in the luteal phase and evaluated by tissue microarray for expression of ER alpha and PR-B. One-hundred and eight endometrial tissue samples were obtained from 12 patients. No differences were found in expression of ER alpha and PR-B among all the specimens with the exception of one sample value. The administration of progesterone during the luteal phase of COH for oocyte donor cycles, either with or without estrogen, does not significantly affect the endometrial expression of ER alpha and PR.

References

Aug 18, 2000·The Journal of Clinical Endocrinology and Metabolism·G R AttiaS E Bulun
Jun 19, 2002·Fertility and Sterility·UNKNOWN American Society for Reproductive Medicine
May 5, 2005·Current Opinion in Obstetrics & Gynecology·Recai Pabuccu, Munire Erman Akar
Nov 23, 2006·Fertility and Sterility·Tsung-Hsuan LaiYulian Zhao
Jan 16, 2007·Molecular Reproduction and Development·Susan A PowellAlfred R Menino
Jul 13, 2007·Human Reproduction Update·H M FatemiP Devroey
Apr 16, 2008·Fertility and Sterility·Beth W RackowHugh S Taylor
May 25, 2011·Biochimica Et Biophysica Acta·Yulian ZhaoEdward Wallach

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Citations

Aug 9, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Limei ZhangCanquan Zhou

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Methods Mentioned

BETA
biopsy
sedation
biopsies

Software Mentioned

SPSS

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