The impact of lymph node density on survival of cervical cancer patients.

British Journal of Cancer
S PolterauerC Grimm

Abstract

To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer. A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medical University of Vienna. Lymph node density, that is, the ratio of positive lymph nodes to the total number of lymph nodes removed, was assessed pathologically. Patients were stratified into two groups according to LND: patients with LND <or=10% and patients with LND >10%. Lymph node density was correlated with clinicopathological parameters by chi(2)-tests. Univariate log-rank tests and multivariate Cox regression models were used to evaluate the association between LND and survival. A significant correlation between LND and FIGO stage (P=0.03), but not patients' age (P=0.2), histological grade (P=0.8), and histological type (P=0.5), was observed. In a univariate survival analysis, LND (P=0.01; P=0.01), FIGO stage (P=0.01; P=0.008), and histological grade (P=0.03; P=0.04) were associated with disease-free and overall survival, respectively. Patients with LND >10% had impaired disease-free and overall survival rates compared with pat...Continue Reading

References

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Citations

May 9, 2013·Case Reports in Oncological Medicine·Sumana PremkumarSamuel J K Abraham
Jul 22, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jeanny KwonKidong Kim
Dec 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ying ChenQuan Hao
Aug 9, 2012·British Journal of Cancer·S PolterauerG Heinze
Nov 26, 2010·British Journal of Cancer·T Van GorpR F Kruitwagen
Aug 18, 2020·Cancer Management and Research·Anyang LiHaiyan Zhu
Mar 28, 2013·Wiener klinische Wochenschrift·Christoph Grimm
Aug 12, 2017·Gynecologic Oncology·Stephan PolterauerUNKNOWN VULCAN Study Collaborative Group
May 15, 2021·The British Journal of Radiology·Aki Kido, Yuji Nakamoto
Aug 14, 2021·Archives of Gynecology and Obstetrics·A JaegerL Woelber
Jan 15, 2020·Oncology Research and Treatment·Peter WidschwendterNikolaus de Gregorio

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