The impact of male circumcision on HIV transmission

The Journal of Urology
Sean M DoylePeter R Carroll

Abstract

Adult male circumcision is currently being implemented as an HIV prevention strategy worldwide. We reviewed the literature on adult male circumcision in the prevention of HIV. A MEDLINE search was used to identify current literature addressing HIV and male circumcision. The data from that literature were reviewed and summarized. Three randomized, controlled trials demonstrate that circumcising adult males reduces the incidence of HIV by 50% to 60%. Adult male circumcision does not seem to have an adverse impact on sexual function. Epidemiological and economic modeling suggests that adult male circumcision can potentially be a highly cost-effective strategy for HIV prevention. Safe, high quality, low cost adult male circumcision services should be made available to regions with a high HIV incidence as part of a comprehensive HIV prevention package.

References

Sep 1, 1990·International Journal of Epidemiology·S MosesF A Plummer
Sep 1, 1988·The Journal of Pediatrics·T E WiswellA F Clemmings
Oct 30, 1986·The New England Journal of Medicine·D Shukla
Apr 9, 1999·Sexually Transmitted Infections·S MosesA R Ronald
Jun 14, 2000·BMJ : British Medical Journal·R Szabo, R V Short
Apr 24, 2004·The Cochrane Database of Systematic Reviews·P SanganiD Wilkinson
May 1, 2004·Science·Rand L Stoneburner, Daniel Low-Beer
Mar 16, 2005·The Lancet Infectious Diseases·N SiegfriedP Williamson
Apr 15, 2006·American Journal of Clinical Pathology·Betty A DonovalRobert C Bailey
Jul 11, 2006·PLoS Medicine·Brian G WilliamsBertran Auvert
Jul 19, 2006·AIDS·Scott G McCoombe, Roger V Short
Oct 10, 2006·Lancet·Edward Mills, Nandi Siegfried
Mar 16, 2007·BMC Infectious Diseases·Nico J D NagelkerkeRobert C Bailey
Apr 5, 2007·Urologia Internationalis·John N KriegerStephen Moses
May 16, 2007·Infectious Disease Clinics of North America·Jeremy NuttallZeda Rosenberg
Mar 5, 2008·AIDS·Helen A WeissCatherine A Hankins
Sep 3, 2008·The Journal of Sexual Medicine·John N KriegerStephen Moses
Sep 18, 2008·Bulletin of the World Health Organization·Robert C BaileyStephanie Rosenberg
Mar 27, 2009·The New England Journal of Medicine·Aaron A R TobianRonald H Gray
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Nandi SiegfriedJimmy Volmink

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Citations

Jul 16, 2011·AIDS Care·Peter S HillUNKNOWN Male Circumcision Acceptability And Impact Study (MCAIS Team)
Aug 18, 2012·The Journal of Sexual Medicine·Carlos E Rodriguez-DiazHermes García
Oct 16, 2015·BMC Public Health·Namuunda MutomboMonica Jamali
Jul 1, 2011·Demographic Research·Michelle Poulin, Adamson S Muula
Oct 22, 2011·Journal of the International AIDS Society·Richard G WamaiJoya Banerjee
Feb 13, 2021·Nature Reviews. Disease Primers·Anita ThomasMaarten Albersen

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