The impact of medical interventions for reducing ototoxicity during treatment for multi-drug resistant tuberculosis.

Acta otorrinolaringológica española
Katijah Khoza-ShangaseLiepollo Ntlhakana

Abstract

The impact of medical interventions for reducing ototoxicity requires focus in contexts where safe non-ototoxic alternative drugs are not yet available. The goal was to investigate the impact of medical intervention strategies for reducing the ototoxic effects of long-term use of aminoglycosides for the treatment of Multi-Drug Resistant Tuberculosis (MDR-TB) in adults at a rural hospital in the Eastern Cape, South Africa. A retrospective record review with a control group design was used, with audiological and medical record reviews of all participants' files over a six-month period. A total of 86 participants (intervention group n=32 and control group n=54) were included. Descriptive and inferential statistics were used to analyze the data. Results revealed progressive hearing loss in both groups, with worsening of thresholds at each subsequent assessment session. The progression of the hearing loss, however, was much slower in the intervention group, with degree of hearing loss being more severe in the control group in the final session of assessment (36.78-71.74dB), when compared to the intervention group (33-44.39dB). Furthermore, the hearing loss in the intervention group remained in the high frequencies while that in the ...Continue Reading

Citations

Feb 12, 2021·The South African Journal of Communication Disorders. Die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings·Katijah Khoza-Shangase, Marina Prodromos

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