The impact of medical therapy on cognitive dysfunction in chronic rhinosinusitis

International Forum of Allergy & Rhinology
Nicholas R RowanZachary M Soler

Abstract

Cognitive dysfunction in chronic rhinosinusitis (CRS) is often overlooked despite potentially broad implications. Earlier work has demonstrated decreased cognitive function in CRS patients at baseline. In this study we sought to prospectively evaluate the impact of initial, appropriate medical therapy on subjective and objective cognitive function, fatigue, and workplace productivity. Adult patients with CRS were prospectively enrolled and completed a robust battery of pretreatment quality-of-life and neurocognitive testing, before undergoing appropriate medical therapy with follow-up testing at 6 weeks. Patient-reported cognitive function was assessed using the Cognitive Failures Questionnaire (CFQ), whereas fatigue was measured with the Fatigue Severity Scale (FSS). Objective cognitive function was assessed using the Automated Neuropsychological Assessment Metrics (ANAM) platform and workplace productivity using the Clinical Trials version of the World Health Organization Health and Work Performance Questionnaire (ctHPQ). Twenty-seven patients were enrolled. Patients demonstrated posttreatment improvement scores on the FSS (4.32 ± 1.78 to 3.28 ± 1.65; p = 0.003), Pittsburgh Sleep Quality Index (8.62 ± 5.06 to 6.85 ± 4.11; p =...Continue Reading

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Citations

Jul 18, 2019·International Forum of Allergy & Rhinology·David W Kennedy
Aug 27, 2019·International Forum of Allergy & Rhinology·Frederick YooZachary M Soler
Dec 5, 2020·International Forum of Allergy & Rhinology·Jacob FriedRodney J Schlosser
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
May 18, 2020·Otolaryngologia polska. The Polish otolaryngology·Karolina Piskadło-ZborowskaKarolina Dżaman
Dec 11, 2021·American Journal of Rhinology & Allergy·Jacob FriedNicholas R Rowan

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