The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila

FEBS Letters
Isabelle DraperPeter B Kang

Abstract

Recessive mutations in multiple epidermal growth factor-like domains 10 (MEGF10) underlie a rare congenital muscle disease known as MEGF10 myopathy. MEGF10 and its Drosophila homolog Draper (Drpr) are transmembrane receptors expressed in muscle and glia. Drpr deficiency is known to result in muscle abnormalities in flies. In the current study, flies that ubiquitously overexpress Drpr, or mouse Megf10, display developmental arrest. The phenotype is reproduced with overexpression in muscle, but not in other tissues, and with overexpression during intermediate stages of myogenesis, but not in myoblasts. We find that tubular muscle subtypes are particularly sensitive to Megf10/Drpr overexpression. Complementary genetic analyses show that Megf10/Drpr and Notch may interact to regulate myogenesis. Our findings provide a basis for investigating MEGF10 in muscle development using Drosophila.

References

Mar 22, 1991·Cell·P Heitzler, P Simpson
Dec 13, 2001·Developmental Cell·V SudarsanH Skaer
Jun 8, 2002·Developmental Biology·Christen Mirth, Michael Akam
Sep 27, 2002·Genesis : the Journal of Genetics and Development·Joseph B Duffy
Feb 18, 2005·Genetics·Adam M DeutschbauerGuri Giaever
Jun 2, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Samanta de JongHelen Sink
Dec 3, 2005·Genes & Development·Daniel M GelperinElizabeth J Grayhack
Feb 4, 2006·Molecular Cell·Richelle SopkoBrenda Andrews
Jan 18, 2007·Journal of Cellular Biochemistry·Andrei V KrivtsovAlexander V Belyavsky
Feb 15, 2007·PLoS Biology·Magnus BaumgardtStefan Thor
Dec 7, 2007·The Journal of Cell Biology·Chet E HoltermanMichael A Rudnicki
Mar 19, 2008·Journal of Muscle Research and Cell Motility·Tariq Maqbool, Krzysztof Jagla
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johnna DohertyMarc R Freeman
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Kailash N Pandey
Jun 3, 2009·Genetics·Jian-Quan NiNorbert Perrimon
Jan 1, 2010·Current Pharmaceutical Design·Malgorzata DaczewskaKrzysztof Jagla
Sep 8, 2010·Current Topics in Developmental Biology·Brendan D'SouzaGerry Weinmaster
Sep 17, 2011·Circulation Research·Matthew J Wolf, Howard A Rockman

❮ Previous
Next ❯

Citations

Apr 17, 2021·American Journal of Human Genetics·Sandra CoppensPeter B Kang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.