The impact of menstrual phase on brachial artery flow-mediated dilatation during handgrip exercise in healthy premenopausal women

Experimental Physiology
Katrina A D'UrzoK E Pyke

Abstract

What is the central question of this study? The aim of this study was to determine the influence of menstrual phase on flow-mediated dilatation in response to sustained, exercise-induced increases in shear stress. What is the main finding and its importance? We showed, for the first time, that in healthy, premenopausal women the flow-mediated dilatation stimulated by exercise-induced increases in shear stress did not fluctuate across two phases of the menstrual cycle, despite significant fluctuations in oestrogen. This suggests that endothelial function is not consistently augmented in the high-oestrogen phase. Flow-mediated dilatation (FMD) in response to a sustained shear-stress stimulus (e.g. via handgrip exercise; HGEX) is emerging as a useful tool for assessing endothelial function; however, the impact of menstrual phase on HGEX-FMD is unknown. The purpose of this study was to determine whether HGEX-FMD fluctuates with cyclical changes in oestrogen concentrations over two discrete phases (low and high oestrogen) of the menstrual cycle. Brachial artery (BA) diameter and blood velocity were assessed with two-dimesional and Doppler ultrasound, respectively. Shear stress was estimated using shear rate (SR = BA blood velocity/B...Continue Reading

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Citations

Jun 16, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Tessa E AdlerNina S Stachenfeld
Nov 2, 2018·Journal of Applied Physiology·Joshua C TremblayKyra E Pyke
Jul 24, 2020·Journal of Applied Physiology·Anna E Stanhewicz, Brett J Wong
May 14, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joshua M BockDarren P Casey
Jul 16, 2020·Radiology. Cardiothoracic Imaging·David R RutkowskiAlejandro Roldán-Alzate
Oct 19, 2019·Experimental Physiology·Anmol T MattuJuan M Murias
Jan 4, 2019·European Journal of Applied Physiology·Joshua C TremblayKyra E Pyke
Oct 29, 2020·Physiological Reports·John D AshleyJ Mikhail Kellawan
Dec 12, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Erika IwamotoDarren P Casey
Nov 3, 2020·Frontiers in Cardiovascular Medicine·Abbi D Lane-Cordova, Samantha Bouknight
Jun 3, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer B WeggenRyan S Garten
Jul 13, 2021·European Journal of Applied Physiology·Ellen C McGarity-ShipleyKyra E Pyke

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