The impact of metastatic sites in advanced pancreatic adenocarcinoma, systematic review and meta-analysis of prospective randomized studies

PloS One
Pedro Luiz Serrano UsónFernando Cotait Maluf

Abstract

The real impact of specific sites of metastasis on prognosis of metastatic pancreatic cancer (MPC) is unknown. To evaluate the association of specific metastatic sites and survival outcomes in MPC a systematic literature review was performed including prospective randomized trials of systemic treatments in metastatic pancreatic cancer indexed in PubMed, Embase and Web of Science. Data regarding systemic treatment regimens, progression free survival and overall survival were extracted. The outcomes were compared using a random effects model. The index I2 and the graphs of funnel plot were used for the interpretation of the data. Of 1,052 abstracts, 7 randomized trials were considered eligible with a combined sample size of 2,975 MPC patients. Combining the studies with meta-analysis, we could see that patients with liver metastasis had a HR for death of 1.53 with 95% CI of 1.15 to 2.02 (p-value 0.003) and HR for risk of progression of 1.96 with 95% CI of 1.28 to 2.99 (p-value 0.002), without significant heterogeneity. Having two or more sites of metastasis comparing to one site did not have impact on overall survival; RR of 1.05 with 95% CI 0.91 to 1.23 (p-value 0.493). In conclusion, liver metastasis confers worse outcomes amon...Continue Reading

References

Nov 26, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam C BergerChristopher G Willett
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemMalcolm J Moore
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Jun 16, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H L KindlerC S Fuchs
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitesh J BoradDavid P Ryan
Apr 11, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DeplanqueP Hammel
Jul 1, 2015·International Journal of Surgery·Marco CannistràBruno Nardo
Aug 6, 2015·The New England Journal of Medicine·Christopher J SweeneyRobert S DiPaola
Feb 26, 2016·Nature·Peter BaileySean M Grimmond
Jun 6, 2017·The New England Journal of Medicine·Karim FizaziUNKNOWN LATITUDE Investigators
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 1, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christos E KyriakopoulosChristopher J Sweeney
Feb 6, 2019·Nature Reviews. Gastroenterology & Hepatology·Eric A CollissonAndrew V Biankin
Aug 30, 2019·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Nov 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H L KindlerC S Fuchs
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DeplanqueP Hammel

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Citations

Aug 6, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Francesco GuerraDiego Coletta
Apr 4, 2021·Cancer Treatment Reviews·Sara De DossoMarkus Borner
Oct 30, 2021·Medicine·Takashi TeraoUNKNOWN Ehime Pancreato-Cholangiology (EPOCH) Study Group

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