The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment

Frontiers in Aging Neuroscience
Youhua XuQuan Zhu

Abstract

Progressive cognitive dysfunction is a central characteristic of diabetic encephalopathy (DE). With an aging population, the incidence of DE is rising and it has become a major threat that seriously affects public health. Studies within this decade have indicated the important role of risk factors such as oxidative stress and inflammation on the development of cognitive impairment. With the recognition of the two-way communication between gut and brain, recent investigation suggests that "microbiota-gut-brain axis" also plays a pivotal role in modulating both cognition function and endocrine stability. This review aims to systemically elucidate the underlying impact of diabetes on cognitive impairment.

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Citations

Sep 4, 2018·Frontiers in Veterinary Science·Emily V BushbyLisa M Collins
Apr 18, 2020·Aging Clinical and Experimental Research·Yunyun ZhangZhiming Yu
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Maria LucaAntonina Luca
Jun 30, 2019·Journal of Agricultural and Food Chemistry·Wen-Qian ZhangYou-Hua Xu

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Methods Mentioned

BETA
glycosylation
nuclear translocation
environmental stress

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