The impact of mode of delivery and gestational age on cord blood hematopoietic stem/progenitor cells

Annals of Hematology
Helen DimitriouMaria Kalmanti

Abstract

Human cord blood has been successfully used as an alternative source of hematopoietic stem cells suitable for transplantation. The aim of this study was to assess the impact of gestational age and the mode of delivery on cord blood hematopoietic stem/progenitor cell characteristics. The mode of delivery does not seem to affect either the replating capacity of hematopoietic progenitors colony-forming unit-granulocyte-macrophage or the cord blood content in CD34(+) cells. The higher percentage of CD34(+) cells in cord blood from preterm deliveries compared to full-term ones indicates that hematopoietic progenitors from preterm cord blood may be suitable for transplantation. These findings should be taken into consideration when selection of cord blood units is required for potential use in transplantation.

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Citations

May 6, 2008·Tissue Engineering. Part B, Reviews·Despoina M ChoumerianouMaria Kalmanti
Dec 8, 2007·American Journal of Respiratory and Critical Care Medicine·Viranuj SueblinvongDaniel J Weiss
Sep 2, 2009·Biochemical and Biophysical Research Communications·Mizue NakajimaYoshitaka Fukunaga
Mar 3, 2012·The Journal of Obstetrics and Gynaecology Research·Fadilah S Abdul WahidZaleha Abdullah Mahdy
Jun 24, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sahar M A HassaneinMahmoud M K H Hellal
Dec 27, 2017·Transfusion·Lionel FaivreAudrey Cras

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